| Gene Symbol | NOS2 |
| Full Name | Nitric Oxide Synthase 2 |
| Aliases | Inducible Nitric Oxide Synthase |
| Chromosome | 17q11.2 |
| Protein Family | Nitric oxide synthase family |
| Protein Type | Enzyme |
| Function | In the immune system, iNOS-mediated NO production serves several critical functions |
| Primary Expression | astrocytes, microglia, and neurons in response to injury or disease |
| Subcellular Localization | ** Cytosol, plasma membrane (neuronal), peroxisomes |
| Molecular Weight | 131 kDa |
| Exons | 26 |
| Pathways | NF-κB |
| GeneCards | NOS2 |
| Human Protein Atlas | NOS2 |
| N-terminal oxygenase domain (1-498 aa) | Contains the catalytic site with binding sites for heme, tetrahydrobiopterin (BH4), L-arginine, and the substrate |
| Associated Diseases | Als, Alzheimer, Cancer, Carcinoma |
| Interactions | ABCB1, ABCG2, AND, APOPTOSIS, ARG1, ATG7 |
| KG Connections | 235 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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