gene

ARG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ARG1
Full Name	Arginase 1
Aliases	Arginase-1, Liver arginase
Chromosome	6q23.2
Function	Urea cycle enzyme, hydrolyzes arginine to ornithine
Primary Expression	the brain, where it plays important roles in modulating nitric oxide (NO) production, polyamine synthesis, and immune cell function[^2]
Molecular Weight	34.7 kDa
Amino Acids	330
Pathways	Urea cycle, Arginine metabolism
UniProt ID	P05089
NCBI Gene ID	383
Ensembl ID	ENSG00000118526
OMIM	608313
GeneCards	ARG1
Human Protein Atlas	ARG1
Associated Diseases	Aging, Alzheimer, Cancer, Dementia, Ms, Tumor
Interactions	ABCG1, TNF, ATG5, PI3K, P62, CD36
KG Connections	226 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ARG1 — AlphaFold P05089 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARG1["ARG1"] -.->|"inhibits"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"associated"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"interacts"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -.->|"inhibits"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ARG1["ARG1"] -->|"activates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    PENK["PENK"] -->|"expressed in"| ARG1["ARG1"]
    style PENK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NCAM1["NCAM1"] -->|"expressed in"| ARG1["ARG1"]
    style NCAM1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DNMT1["DNMT1"] -->|"expressed in"| ARG1["ARG1"]
    style DNMT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT1["AKT1"] -->|"expressed in"| ARG1["ARG1"]
    style AKT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMT["COMT"] -->|"expressed in"| ARG1["ARG1"]
    style COMT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ARG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (188)

Target	Relation	Type	Str
tissue repair	involved_in	process	0.90
MICROGLIA	expressed_in	cell_type	0.90
efferocytosis	regulates	process	0.85
efferocytosis	involved_in	process	0.85
scar formation	involved_in	process	0.85
Inflammation	inhibits	disease	0.75
Inflammation	activates	disease	0.75
unfolded protein response	participates_in	pathway	0.75
INFLAMMATION	activates	gene	0.70
Ms	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Tumor	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
TGF	activates	gene	0.65
TGF-beta signaling	participates_in	pathway	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
DRD2	expressed_in	gene	0.60
DNMT3A	expressed_in	gene	0.60
ABCG1	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
ATG5	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
P62	inhibits	gene	0.60
CD36	inhibits	gene	0.60
LC3	inhibits	gene	0.60
AKT	inhibits	gene	0.60
HMGB1	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
TNF	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
CD163	expressed_in	gene	0.60

Incoming (41)

Source	Relation	Type	Str
Irisin	upregulates	protein	0.90
PENK	expressed_in	gene	0.60
NCAM1	expressed_in	gene	0.60
DNMT1	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
COMT	expressed_in	gene	0.60
DLGAP2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
PPARG	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
NRF2	associated_with	gene	0.60
TNC	activates	gene	0.60
IBA1	activates	gene	0.60
SIRT1	activates	gene	0.60
BDNF	activates	gene	0.60
TGM2	associated_with	gene	0.60
HO1	associated_with	gene	0.60
GLS	activates	gene	0.60
STAT3	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
RNA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GSH	associated_with	gene	0.60
AMPK	activates	gene	0.60
IL-1	activates	gene	0.60
IL-4	activates	gene	0.60
DEPRESSION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
AMYLOID	associated_with	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
PD-L1	therapeutic_target	gene	0.60
HGF	therapeutic_target	gene	0.60
AHR	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARG1

Understanding Entity Pages

Wiki Pages (21)

ARG1 — Arginase 1

Corticobasal Syndrome (CBS)

TREM2 Mechanism Hub

TGF-β Signaling in Parkinson's Disease

Neuroinflammation in Amyotrophic Lateral Sclerosis

Neuroinflammation Microglia

Microglia Activation Mechanism

Neuroinflammation Pathway

CSF1R Inhibitors for Parkinson's Disease

Lactoferrin Neuroprotection in Neurodegenerative Diseases

Neuroinflammation in Neurodegeneration

mTOR Signaling in Neurodegeneration

Microglia and neuroinflammation in Alzheimer's Disease

Parabacteroides goldsteinii Mitigation of Parkinsonism in LRRK2 Mice

IL13 — Interleukin 13

Neuroinflammation Targeting Therapies

Microglia-Targeted Nanoparticles for CNS Delivery

Specialized Pro-Resolving Mediator (SPM) Therapies for Neurodegeneration

Exercise and Physical Activity for Neuroprotection