| Gene Symbol | PAHPROTEIN |
| Protein Type | Enzyme |
| Function | is a crucial enzyme in phenylalanine metabolism, catalyzing the rate-limiting step in the catabolic pathway that converts the essential amino acid L-phenylalanine to L-tyrosine [blau2010](https://p... |
| Primary Expression | the liver, where it functions as a homotetramer to metabolize the majority of dietary phenylalanine |
| Molecular Weight | 52 kDa |
| Amino Acids | 507 aa |
| GeneCards | PAHPROTEIN |
| Human Protein Atlas | PAHPROTEIN |
| Ferrous Iron (Fe²⁺) | The catalytic center contains a tightly bound iron ion that participates directly in the hydroxylation reaction |
| Tetrahydrobiopterin (BH₄) | The essential cofactor that serves as both a reducing agent and participant in the catalytic cycle |
| Molecular Oxygen (O₂) | Required as the oxidant for the hydroxylation reaction |
| Associated Diseases | Aging, Als, Alzheimer, Atherosclerosis, Autism |
| Interactions | ABCC8, AND, APAF1, APOPTOSIS, CALR, CANCER |
| KG Connections | 203 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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