CALR

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CALR is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with Als, Cancer, Ms. Connected to 26 entities in the SciDEX knowledge graph.

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graph TD
    CALR["<b>CALR</b>"]
    Tumor{"Tumor"}
    CALR -->|"associated with"| Tumor
    Ms{"Ms"}
    CALR -->|"associated with"| Ms
    Cancer{"Cancer"}
    CALR -->|"activates"| Cancer
    CALR -->|"activates"| Tumor
    CALR -->|"activates"| Ms
    Als{"Als"}
    CALR -->|"expressed in"| Als
    CALR -->|"expressed in"| Cancer
    Apoptosis(["Apoptosis"])
    CALR -->|"contributes to"| Apoptosis
    GSDME["GSDME"]
    CALR -->|"activates"| GSDME
    CALR -->|"therapeutic target"| Apoptosis
    Pyroptosis(["Pyroptosis"])
    CALR -->|"activates"| Pyroptosis
    S100A6["S100A6"]
    CALR -->|"associated with"| S100A6
    WLS["WLS"]
    WLS -->|"interacts with"| CALR
    BCL2["BCL2"]
    BCL2 -->|"regulates"| CALR
    PYROPTOSIS["PYROPTOSIS"]
    PYROPTOSIS -->|"activates"| CALR
    style CALR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0