| Gene Symbol | PPARGC1A |
| Full Name | PPARG Coactivator 1 Alpha |
| Chromosome | 4p15.31 |
| Protein Family | PGC-1 transcriptional coactivator family |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | PPARGC1A encodes PGC-1α (PPAR gamma coactivator 1-alpha), a transcriptional coactivator that serves as a master regulator of mitochondrial biogenesis and cellular energy metabolism. |
| Mechanism of Action | Small molecule modulator of transcriptional coactivator function |
| Primary Expression | tissues with high metabolic demand: - Brain: Neurons (especially in substantia nigra, hippocampus), [astrocytes](/entities/as |
| Subcellular Localization | Nucleus, mitochondria, cytoplasm |
| Druggability | Low (0.43) |
| Clinical Stage | Approved |
| Molecular Weight | 91 kDa (full-length human) |
| Amino Acids | 798 (canonical isoform) |
| Pathways | Apoptosis, Autophagy, Cell Cycle, Er Stress, Ferroptosis |
| UniProt ID | Q9UBX2 |
| NCBI Gene ID | 10891 |
| Ensembl ID | ENSG00000109819 |
| OMIM | 604517 |
| GeneCards | PPARGC1A |
| Human Protein Atlas | PPARGC1A |
| Associated Diseases | ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, CANCER |
| Known Drugs/Compounds | reactive oxygen species, THYROID_HORMONE, Aloe-emodin, Kaixinsan, glitazones, piperine |
| Interactions | PRKAA1, ATG10, SIRT1, DNM1L, BAX, LC3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito |
| KG Connections | 992 knowledge graph edges |
| Databases | GeneCardsHPASTRING |