biomarker 1,432 words KG: NFM 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Neurofilament Medium Chain (NfM) - Biomarker

🔬 Protein Info
Gene SymbolNEFM
Full NameNeurofilament Medium Chain
AliasesNFM
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFM gene on chromosome 8p21, adjacent to the NEFL gene.
Primary ExpressionAxon, neuronal cytoplasm
Amino Acids916 aa
Exons10
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP12036
NCBI Gene ID4741
Ensembl IDENSG00000104722
GeneCardsNEFM
Human Protein AtlasNEFM
Associated DiseasesParkinson
InteractionsNPY, POMC, PRKN, RBFOX3, RNA, AIF1
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Multi-Modal Stress Response Harmonization
Score: 0.60
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57

Related Analyses (16)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (12)

PGC-1α (PPARGC1A)
protein · KG edge: regulates
ER Stress and Unfolded Protein Response in Corticobasal
mechanism · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
SNCA — Alpha-Synuclein
gene · KG edge: regulates
SFPQ Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

NFM regulates LMX1B
NFM regulates NURR1
NFM regulates SNCA
NFM associated_with HNRNPA1
NFM regulates PGC1ALPHA
NFM regulates PARK7
NFM regulates PINK1
NFM co_expressed_with NURR1
NFM co_expressed_with PARK7
NFM activates NPY