gene 3,060 words KG: PARK7
Contents

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

🧬 Gene Info
Gene SymbolPARK7
Full NameParkinsonism Associated Deglycase (DJ-1)
AliasesPage for PARK7 Gene
Chromosome1p36.23
Protein TypeProtein
FunctionDJ-1 has multiple cellular functions
Primary ExpressionHigh in brain (substantia nigra), testis, kidney
Subcellular LocalizationCytoplasm, nucleus, mitochondria
Molecular Weight20 kDa
Amino Acids189 aa
PathwaysAlpha-Synuclein, Autophagy, Epigenetic, Er Stress, Inflammasome
UniProt IDQ99497
GeneCardsPARK7
Human Protein AtlasPARK7
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsACETYL-COA, AD, AGING, AKT, Alpha-Synuclein, ALS
KG Connections608 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

ABCA7 (Redirect)
redirect · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

PARK7 associated_with neurodegeneration
PARK7 regulates SOD1
BACE1 associated_with PARK7
SOD1 regulates PARK7
PARK7 associated_with SOD1
PARK7 associated_with TAU
LRRK2 associated_with PARK7
PARK7 co_discussed SOD1
PARK7 co_discussed TAU
LRRK2 co_discussed PARK7

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