| Gene Symbol | PRESENILIN |
| Aliases | PRESENILINPROTEIN |
| Chromosome | 14q24.3 |
| Primary Expression | Ca1, Hippocampus, Cortex, Parietal Lobe, Gray Matter |
| Pathways | autophagy pathway, proteasome pathway, Oxidative Stress, Apoptosis, Autophagy |
| GeneCards | PRESENILIN |
| Human Protein Atlas | PRESENILIN |
| Nine transmembrane domains | Embedded in the lipid bilayer |
| Two aspartate residues | Located in transmembrane domains 6 and 7, essential for proteolytic activity |
| N-terminal and C-terminal fragments | Generated by endoproteolysis |
| Pen-2, APH-1, and NCT | Essential co-factors in the gamma-secretase complex |
| Initial cleavage | APP is cleaved by BACE1 at the beta-site |
| Gamma-secretase cleavage | Occurs within the transmembrane domain |
| A-beta production | Generates A-beta peptides of varying lengths (A-beta 37-43) |
| Notch processing | Gamma-secretase also cleaves Notch receptors |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer Disease, Alzheimer'S Disease |
| Interactions | ABCD3, ACHE, Actin, ADAM10, ALS, ALZHEIMER |
| KG Connections | 1013 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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