| Gene Symbol | RIPK3 |
| Aliases | RIPK3PROTEIN |
| Function | Necrosome formation: RHIM-RHIM interactions recruit RIPK3 to activated RIPK1; RIPK1 undergoes conformational change exposing its RHIM |
| Primary Expression | Restrictive — immune cells, neurons, some epithelial cells |
| Molecular Weight | 56.8 kDa (527 amino acids) |
| Amino Acids | 527 aa |
| Pathways | Apoptosis, Autophagy, Dna Methylation, Ferroptosis, Immune Response |
| GeneCards | RIPK3 |
| Human Protein Atlas | RIPK3 |
| Feature | RIPK1 |
| Kinase domain | Catalytically active |
| RHIM domain | Present |
| Death domain | Present (C-terminus) |
| Necrosome role | Initiator |
| Kinase inhibitors | Multiple in development |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS |
| Known Drugs/Compounds | RAPAMYCIN, Adeno-Associated Virus, THSG, Mitochondrial ROS, Ponicidin, HSYA |
| Interactions | DRP1, CHOP, BECN1, PTEN, DDIT3, NBR1 |
| KG Connections | 1470 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |