concept

ACOD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACOD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

49Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ACOD1
Key Genes/Proteins	SQSTM1, NFE2L2, itaconate, TNF, TLR, NF-κB
Related Diseases	itaconate, spinal cord injury, Lymphoma
Related Pathways	Immune Response

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ACOD1["ACOD1"]
    style ACOD1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ACOD1 -.->|"inhibits"| neuroinflammation["neuroinflammation"]
    ACOD1 -.->|"inhibits"| oxidative_stress["oxidative stress"]
    ACOD1 -->|"interacts"| SQSTM1([SQSTM1])
    ACOD1 -->|"produces"| itaconate(itaconate)
    ACOD1 -->|"regulates"| macrophage_activation["macrophage activation"]
    ACOD1 -.->|"protects against"| spinal_cord_injury["spinal cord injury"]
    ACOD1 -->|"activates"| Immune_Response["Immune Response"]
    ACOD1 -->|"activates"| CYTOKINES([CYTOKINES])
    ACOD1 -->|"activates"| Lymphoma["Lymphoma"]
    NFE2L2([NFE2L2]) -->|"regulates"| ACOD1
    TNF([TNF]) -->|"activates"| ACOD1
    TLR([TLR]) -->|"activates"| ACOD1
    NF__B(["NF-kappaB"]) -->|"regulates"| ACOD1
    DRD2([DRD2]) -->|"regulates"| ACOD1
    IRF1([IRF1]) -->|"activates"| ACOD1
    CANCER([CANCER]) -->|"activates"| ACOD1

Outgoing (49)

Target	Relation	Type	Str
neuroinflammation	inhibits	process	0.94
oxidative stress	inhibits	process	0.94
SQSTM1	interacts_with	protein	0.92
itaconate	produces	phenotype	0.90
macrophage activation	regulates	process	0.90
spinal cord injury	protects_against	disease	0.87
itaconate	encodes	protein	0.85
Immune Response	activates	pathway	0.70
CYTOKINES	activates	gene	0.70
Lymphoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Lupus	activates	disease	0.65
Autoimmune	activates	disease	0.65
Rheumatoid Arthritis	activates	disease	0.65
Als	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Infection	activates	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
RIPK3	activates	gene	0.60
TFEB	activates	gene	0.60
NLRP3	activates	gene	0.60
FOXP3	activates	gene	0.60
IL-6	activates	gene	0.60
Differentiation	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
TNF	activates	gene	0.60
MYD88	activates	gene	0.60
OXIDATIVE STRESS	implicated_in	gene	0.60
NF-ΚB	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
Oxidative Stress	implicated_in	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Microglia	activates	cell_type	0.60
Rb	activates	protein	0.60
Actin	activates	protein	0.60
GSDMD	regulates	gene	0.60
NLRP3	regulates	gene	0.60
TFEB	regulates	gene	0.60
pyroptosis	participates_in	pathway	0.60
Spinal Cord	expressed_in	brain_region	0.55
macrophages	expressed_in	cell_type	0.55

Incoming (11)

Source	Relation	Type	Str
NFE2L2	regulates	protein	0.89
TNF	activates	protein	0.80
TLR	activates	protein	0.80
NF-κB	regulates	protein	0.80
DRD2	regulates	gene	0.80
IRF1	activates	gene	0.60
CANCER	activates	gene	0.60
P62	activates	gene	0.60
NRF2	activates	gene	0.60
KEAP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ACOD1

Understanding Entity Pages

Wiki Pages (5)

Microglial Metabolic Reprogramming

TNF - Tumor Necrosis Factor

DRD2 Gene