| Gene Symbol | SIRT6 |
| Aliases | SIRT6PROTEIN |
| Chromosome | 19p13.3<br> |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | SIRT6 exhibits multiple enzymatic activities |
| Mechanism of Action | Small molecule activation or inhibition of NAD+-dependent deacetylase activity |
| Primary Expression | most tissues:
- Brain: cortex, hippocampus, cerebellum
- Substantia nigra
- Low expression but |
| Subcellular Localization | ** Nucleus, Mitochondria<br> |
| Druggability | Low (0.41) |
| Clinical Stage | Phase I |
| Molecular Weight | 36 kDa |
| Pathways | NF-κB |
| UniProt ID | Q9Y5W5 |
| NCBI Gene ID | 51588 |
| Ensembl ID | ENSG00000173120 |
| GeneCards | SIRT6 |
| Human Protein Atlas | SIRT6 |
| Associated Diseases | AGING, ALS, AMYOTROPHIC LATERAL SCLEROSIS, Alzheimer |
| Known Drugs/Compounds | Withaferin A, nicotinamide, rapamycin |
| Interactions | EGR2, PARP1, CD38, HNRNPA2B1, NAMPT, CD36 |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SIRT6-NAD+ Axis Enhancement Therapy |
| KG Connections | 433 knowledge graph edges |
| Databases | GeneCardsHPASTRING |