protein 2,088 words KG: SLC32A1PROTEIN
Contents

SLC32A1PROTEIN Protein

🔬 Protein Info
Gene SymbolSLC32A1
AliasesSLC32A1PROTEIN
FunctionSLC32A1 encodes the vesicular GABA transporter (VGAT), also known as the vesicular inhibitory amino acid transporter (VIAAT).
Pathwaysautophagy pathway, Apoptosis, Necroptosis, Pyroptosis
Ensembl IDENSG00000103838
GeneCardsSLC32A1
Human Protein AtlasSLC32A1
N-terminal cytoplasmic domainContains sorting signals for synaptic vesicle targeting
Transmembrane domain 1-12Forms the translocation channel
C-terminal cytoplasmic tailInvolved in protein-protein interactions
Parvalbumin (PV)-positive interneuronsFast-spikingBasket cells targeting neuronal somata
Rebound-spiking neuronsIncluding neurogliaform cells
Associated DiseasesAls, Cancer, Tumor
InteractionsGAD1, GRIA2, INS, NPY, PVALB, SLC17A6
KG Connections100 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (5)

SASP-Mediated Complement Cascade Amplification
Score: 0.82
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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