GRIA2

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GRIA2 encodes the GluA2 AMPA receptor subunit, critical for calcium permeability control and synaptic plasticity. RNA editing deficiency contributes to ALS and AD.

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graph TD
    GRIA2["<b>GRIA2</b>"]
    Aging{"Aging"}
    GRIA2 -->|"activates"| Aging
    Cardiovascular{"Cardiovascular"}
    GRIA2 -->|"activates"| Cardiovascular
    PRKN["PRKN"]
    GRIA2 -->|"activates"| PRKN
    Mitophagy(["Mitophagy"])
    GRIA2 -->|"activates"| Mitophagy
    Autophagy(["Autophagy"])
    GRIA2 -->|"activates"| Autophagy
    PARKIN["PARKIN"]
    GRIA2 -->|"activates"| PARKIN
    XBP1["XBP1"]
    GRIA2 -->|"activates"| XBP1
    COX4I1["COX4I1"]
    GRIA2 -->|"activates"| COX4I1
    HSPD1["HSPD1"]
    GRIA2 -->|"activates"| HSPD1
    PTEN["PTEN"]
    GRIA2 -->|"activates"| PTEN
    LC3B["LC3B"]
    GRIA2 -->|"activates"| LC3B
    MITOCHONDRIA["MITOCHONDRIA"]
    GRIA2 -->|"activates"| MITOCHONDRIA
    MYO7A["MYO7A"]
    MYO7A -->|"activates"| GRIA2
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"activates"| GRIA2
    OPTN["OPTN"]
    OPTN -->|"activates"| GRIA2
    PARKIN -->|"activates"| GRIA2
    PINK1["PINK1"]
    PINK1 -->|"activates"| GRIA2
    XBP1 -->|"activates"| GRIA2
    ATF3["ATF3"]
    ATF3 -->|"activates"| GRIA2
    TOMM20["TOMM20"]
    TOMM20 -->|"activates"| GRIA2
    PTEN -->|"activates"| GRIA2
    USP30["USP30"]
    USP30 -->|"activates"| GRIA2
    FOXO3["FOXO3"]
    FOXO3 -->|"activates"| GRIA2
    HSPD1 -->|"activates"| GRIA2
    style GRIA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0