gene

SLC17A6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC17A6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

176Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SLC17A6 (VGLUT2): Vesicular glutamate transporter essential for excitatory neurotransmission, implicated in Alzheimer's disease, Parkinson's disease, and psychiatric disorders

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🧬 Gene Info

Gene Symbol	SLC17A6
Full Name	Solute Carrier Family 17 Member 6
Aliases	VGLUT2
Chromosome	11q14.1
Protein Type	Transporter
Function	is a critical vesicular glutamate transporter responsible for packaging glutamate into synaptic vesicles at excitatory synapses.
Primary Expression	specific neuronal populations:
Molecular Weight	64 kDa
Amino Acids	582 aa
Exons	16
Pathways	Epigenetic, Synaptic Plasticity, Synaptic Vesicle, autophagy pathway
UniProt ID	[Q9P2U7](https://www.uniprot.org/uniprot/Q9P2U7)
Ensembl ID	ENSG00000164690
GeneCards	SLC17A6
Human Protein Atlas	SLC17A6
Associated Diseases	ALS, Cancer, Tumor
Interactions	VGLUT1, TAU, VGLUT2, SNAP25, GRIA2, PVALB
KG Connections	176 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC17A6["SLC17A6"]
    Ms["Ms"]
    Parkinson["Parkinson"]
    Als["Als"]
    Aging["Aging"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Cancer["Cancer"]
    N6_OHDA["6-OHDA"]
    PARKINSON["PARKINSON"]
    VGLUT2["VGLUT2"]
    AND["AND"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    SLC12A5["SLC12A5"]
    SYN2["SYN2"]
    APOPTOSIS["APOPTOSIS"]
    ALZHEIMER["ALZHEIMER"]
    RNA["RNA"]
    SLC17A6 -.->|"inhibits"| Ms
    SLC17A6 -.->|"inhibits"| Parkinson
    SLC17A6 -.->|"inhibits"| Als
    SLC17A6 -.->|"inhibits"| Aging
    SLC17A6 -->|"therapeutic_tar"| Pyroptosis
    SLC17A6 -->|"therapeutic_tar"| Necroptosis
    SLC17A6 -->|"therapeutic_tar"| Dementia
    SLC17A6 -->|"therapeutic_tar"| Alzheimer
    SLC17A6 -.-|"associated"| Als
    SLC17A6 -.-|"associated"| Cancer
    SLC17A6 -.->|"inhibits"| N6_OHDA
    SLC17A6 -.->|"inhibits"| PARKINSON
    SLC17A6 -.-|"associated"| VGLUT2
    SLC17A6 -.->|"inhibits"| AND
    SLC17A6 -.->|"inhibits"| PARKINSON_S_DISEASE
    SLC17A6 -->|"biomarker_for"| SLC12A5
    SLC17A6 -->|"biomarker_for"| SYN2
    SLC17A6 -->|"therapeutic_tar"| APOPTOSIS
    SLC17A6 -->|"therapeutic_tar"| ALZHEIMER
    SLC17A6 -->|"therapeutic_tar"| RNA
    style SLC17A6 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (102)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Ms	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
VGLUT2	associated_with	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
NPY	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SLC32A1	associated_with	gene	0.60
SST	associated_with	gene	0.60
GRIA2	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
VGLUT1	activates	gene	0.60
TAU	activates	gene	0.60
VGLUT2	activates	gene	0.60
Synaptic Vesicle	activates	pathway	0.60
SLC17A7	biomarker_for	gene	0.60
Rb	associated_with	protein	0.60
SLC32A1	interacts_with	gene	0.60
SST	interacts_with	gene	0.60
SLC17A7	binds_to	gene	0.60
SNAP25	binds_to	gene	0.60
SST	binds_to	gene	0.60
SQSTM1	activates	gene	0.60
TRPM2	activates	gene	0.60
ULK1	activates	gene	0.60
6-OHDA	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
AND	inhibits	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Incoming (74)

Source	Relation	Type	Str
ERK1	inhibits	gene	0.60
SLC17A7	biomarker_for	gene	0.60
SLC17A7	associated_with	gene	0.60
SLC17A7	activates	gene	0.60
KDM6B	activates	gene	0.60
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
SLC32A1	associated_with	gene	0.60
NPY	associated_with	gene	0.60
SST	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
GRIA2	associated_with	gene	0.60
VGLUT2	activates	gene	0.60
VGLUT1	activates	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
TAU	activates	gene	0.60
SLC12A5	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
GRIA2	interacts_with	gene	0.60
NPY	interacts_with	gene	0.60
PVALB	interacts_with	gene	0.60
NPY	binds_to	gene	0.60
PVALB	binds_to	gene	0.60
CD44	associated_with	gene	0.60
GRN	associated_with	gene	0.60
HSP90AB1	associated_with	gene	0.60
ATG5	activates	gene	0.60
BECN1	activates	gene	0.60
CAMK2	activates	gene	0.60
CASP3	activates	gene	0.60
DMPK	activates	gene	0.60
GFAP	activates	gene	0.60
HIF1A	activates	gene	0.60
HMGCR	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PIK3C3	activates	gene	0.60
PLP1	activates	gene	0.60
PRKDC	activates	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
INS	associated_with	gene	0.60
HUB GENES	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC17A6

Understanding Entity Pages

Summary

Wiki Pages (21)

Cochlear Nuclei Neurons

Claustrum Neurons

Supramammillary Neurons

Synaptic Vesicle Cycle

VGLUT2 Gene

SLC17A6 Gene

mossy-cells-dentate-gyrus

Glutamate Excitotoxicity Pathway in Neurodegeneration

synaptic-vesicle-cycling-neurodegeneration

Precuneus Cortical Neurons

Olivary Complex Inferior Olive Neurons

Reticularis Pontis Oralis Neurons

Cortical Stellate Cells

Anterior Olfactory Nucleus (AON) Neurons

pontine-nucleus-neurons

Pre-Bötzinger Complex - Expanded

slc17a8

Lateral Habenula Neurons

Ventral Tegmental Area Glutamatergic Neurons