gene

GAD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

190Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Glutamate Decarboxylase 1

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🧬 Gene Info

Gene Symbol	GAD1
Full Name	Glutamate Decarboxylase 1
Chromosome	2q31.1
Protein Type	Receptor
Function	It plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expression	regions affected in Parkinson disease
Pathways	Mapk, autophagy pathway
UniProt ID	P23284
NCBI Gene ID	2571
Ensembl ID	ENSG00000118592
OMIM	605119
GeneCards	GAD1
Human Protein Atlas	GAD1
Taxonomy	ID
Cell Ontology (CL)	CL:0000118
Associated Diseases	epilepsy
Known Drugs/Compounds	rapamycin
Interactions	SST, TRKB, NTF3, CALB2, CALB1, PVALB
KG Connections	190 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAD1 — AlphaFold P23284 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GAD1["GAD1"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Depression["Depression"]
    Als["Als"]
    Schizophrenia["Schizophrenia"]
    SYP["SYP"]
    ASTROCYTES["ASTROCYTES"]
    DEMENTIA["DEMENTIA"]
    SLC32A1["SLC32A1"]
    GRIN2A["GRIN2A"]
    PVALB["PVALB"]
    SNAP25["SNAP25"]
    Apoptosis["Apoptosis"]
    Endothelial["Endothelial"]
    Neuron["Neuron"]
    Astrocyte["Astrocyte"]
    GAD1 -->|"therapeutic_tar"| Pyroptosis
    GAD1 -->|"therapeutic_tar"| Necroptosis
    GAD1 -->|"therapeutic_tar"| Dementia
    GAD1 -->|"therapeutic_tar"| Alzheimer
    GAD1 -.->|"inhibits"| Depression
    GAD1 -->|"expressed in"| Als
    GAD1 -->|"expressed in"| Schizophrenia
    GAD1 -->|"expressed in"| Depression
    GAD1 -->|"biomarker_for"| SYP
    GAD1 -->|"therapeutic_tar"| ASTROCYTES
    GAD1 -->|"therapeutic_tar"| DEMENTIA
    GAD1 -->|"biomarker_for"| SLC32A1
    GAD1 -->|"biomarker_for"| GRIN2A
    GAD1 -->|"biomarker_for"| PVALB
    GAD1 -->|"biomarker_for"| SNAP25
    GAD1 -->|"therapeutic_tar"| Apoptosis
    GAD1 -->|"therapeutic_tar"| Endothelial
    GAD1 -->|"therapeutic_tar"| Neuron
    GAD1 -->|"therapeutic_tar"| Astrocyte
    GAD1 -.-|"associated"| PVALB
    style GAD1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (118)

Target	Relation	Type	Str
PARKINSON'S DISEASE	treats	disease	0.80
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Depression	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Anxiety	expressed_in	disease	0.65
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	associated_with	gene	0.60
SST	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
NTF3	activates	gene	0.60
CALB2	inhibits	gene	0.60
CALB1	inhibits	gene	0.60
PVALB	inhibits	gene	0.60
S100B	activates	gene	0.60
GFAP	activates	gene	0.60
Purkinje	associated_with	cell_type	0.60
DLG4	expressed_in	gene	0.60
SLC17A7	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
NPY	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
GAD2	inhibits	gene	0.60
CREB1	activates	gene	0.60
BDNF	inhibits	gene	0.60
FOS	activates	gene	0.60
EGR1	activates	gene	0.60
NTRK2	inhibits	gene	0.60
MAPK1	activates	gene	0.60
NTRK3	activates	gene	0.60
SATB2	expressed_in	gene	0.60
Purkinje	encodes	cell_type	0.60
Rb	expressed_in	protein	0.60
Purkinje cells	expressed_in	cell_type	0.60
cerebellum	expressed_in	brain_region	0.60
SQSTM1	interacts_with	gene	0.60
epilepsy	associated_with	disease	0.60

Incoming (72)

Source	Relation	Type	Str
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
NPY	inhibits	gene	0.60
GAD2	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
EGR1	activates	gene	0.60
FOS	activates	gene	0.60
NTRK2	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
SATB2	expressed_in	gene	0.60
GRIN2A	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
TRKB	inhibits	gene	0.60
NTF3	activates	gene	0.60
GFAP	activates	gene	0.60
S100B	activates	gene	0.60
CALB2	inhibits	gene	0.60
GABARAP	interacts_with	gene	0.60
DMD	interacts_with	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
DEPRESSION	inhibits	gene	0.60
DEPRESSION	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AND	associated_with	gene	0.60
ANXIETY	expressed_in	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
GABA	inhibits	gene	0.60
NEURON	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
HUB GENES	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GAD1

Understanding Entity Pages

Summary

Wiki Pages (21)

Cerebellar Basket Cells

gabaergic-dysfunction

Claustrum Neurons

Allen Human Brain Atlas

Cortical Ivy Cells

NCT07172295: Low-Intensity Focused Ultrasound for PD Tremor

PD Drug Combination Therapy Matrix

Dorsolateral Prefrontal Cortex (DLPFC) Pyramidal Neurons

GABAergic Neurons — Cell Type Hierarchy

Olfactory Bulb Granule Cells

GLUL — Glutamine Synthetase

GABAergic Signaling Pathway in Neurodegeneration

Precuneus Cortical Neurons

Cortical Layer 1 Neurons

GRIN2A Protein

Interpeduncular-Nucleus-in-Parkinsons-Disease

Interneurons — Cell Type Hierarchy

Nucleus Accumbens Shell Median Neurons

Gamma-Aminobutyric Acid (GABA)

Striatal Interneurons in Huntington's Disease