gene

GAD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

184Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

18Debates

Summary

Glutamate Decarboxylase 1

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🧬 Gene Info

Gene Symbol	GAD1
Full Name	Glutamate Decarboxylase 1
Chromosome	2q31.1
Protein Type	Receptor
Function	It plays critical roles in ciliary signaling, neuronal migration, and synaptic function.
Primary Expression	regions affected in Parkinson disease
Pathways	Mapk, autophagy pathway
UniProt ID	P23284
NCBI Gene ID	2571
Ensembl ID	ENSG00000118592
OMIM	605119
GeneCards	GAD1
Human Protein Atlas	GAD1
Associated Diseases	epilepsy
Known Drugs/Compounds	rapamycin
Interactions	AMPK, APP, ASTROCYTES, Bdnf, BDNF, CALB1
SciDEX Hypotheses	Astrocyte Reactivity Subtype Targeting GABA Synthe
KG Connections	184 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAD1 — AlphaFold P23284 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glutamate Decarboxylase 1

gene · 914 words

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Pathway Diagram

graph TD
    GAD1["GAD1"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Depression["Depression"]
    Als["Als"]
    Schizophrenia["Schizophrenia"]
    SYP["SYP"]
    ASTROCYTES["ASTROCYTES"]
    DEMENTIA["DEMENTIA"]
    SLC32A1["SLC32A1"]
    GRIN2A["GRIN2A"]
    PVALB["PVALB"]
    SNAP25["SNAP25"]
    Apoptosis["Apoptosis"]
    Endothelial["Endothelial"]
    Neuron["Neuron"]
    Astrocyte["Astrocyte"]
    GAD1 -->|"therapeutic_tar"| Pyroptosis
    GAD1 -->|"therapeutic_tar"| Necroptosis
    GAD1 -->|"therapeutic_tar"| Dementia
    GAD1 -->|"therapeutic_tar"| Alzheimer
    GAD1 -.->|"inhibits"| Depression
    GAD1 -->|"expressed in"| Als
    GAD1 -->|"expressed in"| Schizophrenia
    GAD1 -->|"expressed in"| Depression
    GAD1 -->|"biomarker_for"| SYP
    GAD1 -->|"therapeutic_tar"| ASTROCYTES
    GAD1 -->|"therapeutic_tar"| DEMENTIA
    GAD1 -->|"biomarker_for"| SLC32A1
    GAD1 -->|"biomarker_for"| GRIN2A
    GAD1 -->|"biomarker_for"| PVALB
    GAD1 -->|"biomarker_for"| SNAP25
    GAD1 -->|"therapeutic_tar"| Apoptosis
    GAD1 -->|"therapeutic_tar"| Endothelial
    GAD1 -->|"therapeutic_tar"| Neuron
    GAD1 -->|"therapeutic_tar"| Astrocyte
    GAD1 -.-|"associated"| PVALB
    style GAD1 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (114)

Target	Relation	Type	Str
PARKINSON'S DISEASE	treats	disease	0.80
Schizophrenia	expressed_in	disease	0.65
Depression	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Anxiety	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Neuron	associated_with	cell_type	0.60
Ras	inhibits	protein	0.60
SATB2	expressed_in	gene	0.60
Purkinje	encodes	cell_type	0.60
cerebellum	expressed_in	brain_region	0.60
ASTROCYTES	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
Interneuron	associated_with	cell_type	0.60
DEPRESSION	expressed_in	gene	0.60
Purkinje	associated_with	cell_type	0.60
autophagy pathway	participates_in	pathway	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
NPY	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
GAD2	inhibits	gene	0.60
SYP	biomarker_for	gene	0.60
CREB1	activates	gene	0.60
BDNF	inhibits	gene	0.60
FOS	activates	gene	0.60
EGR1	activates	gene	0.60
NTRK2	inhibits	gene	0.60
MAPK1	activates	gene	0.60
NTRK3	activates	gene	0.60
GABA	inhibits	gene	0.60
Interneuron	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
ASTROCYTES	activates	gene	0.60
Mapk	activates	pathway	0.60
Astrocyte	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
GABAergic neurons	expressed_in	cell_type	0.60
SST	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
NTF3	activates	gene	0.60

Incoming (70)

Source	Relation	Type	Str
GABA	associated_with	gene	0.60
GAD2	inhibits	gene	0.60
BDNF	associated_with	gene	0.60
MAPK1	activates	gene	0.60
CREB1	activates	gene	0.60
NTRK3	activates	gene	0.60
EGR1	activates	gene	0.60
FOS	activates	gene	0.60
NTRK2	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
GRIN2A	biomarker_for	gene	0.60
TRKB	inhibits	gene	0.60
rapamycin	targets	drug	0.60
NPY	inhibits	gene	0.60
GABARAP	interacts_with	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AMPK	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
HUB GENES	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ANXIETY	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
SATB2	expressed_in	gene	0.60
CALB2	inhibits	gene	0.60
DEPRESSION	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
NTF3	activates	gene	0.60
GFAP	activates	gene	0.60
S100B	activates	gene	0.60
DEPRESSION	inhibits	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
SYN2	biomarker_for	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
DMD	interacts_with	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60