| Gene Symbol | SRCPROTEIN |
| Chromosome | 20q11.23. |
| Protein Type | Kinase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | (Zhang et al |
| Molecular Weight | 60 kDa |
| GeneCards | SRCPROTEIN |
| Human Protein Atlas | SRCPROTEIN |
| N-terminal myristoylation site | Gly2 is myristoylated for membrane anchoring |
| Unique domain (residues 1-80) | Distinguishes c-Src from other SFKs; mediates protein-protein interactions |
| SH3 domain (residues 84-143) | Binds proline-rich motifs (PXXP); involved in autoinhibition |
| SH2 domain (residues 150-225) | Binds phosphotyrosine residues; critical for regulatory interactions |
| C-terminal regulatory tail | Tyr527 (human) is phosphorylated by CSK for autoinhibition |
| AMPA receptor trafficking | Regulates AMPAR endocytosis and surface expression during long-term depression |
| PSD-95 interactions | Modifies postsynaptic density scaffolding and receptor clustering |
| Associated Diseases | AD, ALI, Als, Alzheimer, Autism |
| Known Drugs/Compounds | DEP, DOP |
| Interactions | ABL1, ACE, ACSL4, AD, ADRB2, AGING |
| KG Connections | 1076 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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