protein 2,147 words KG: STATHMIN
Contents

STATHMIN Protein

🔬 Protein Info
Gene SymbolSTATHMIN
Full NameStathmin-1 (Oncoprotein 18)
Chromosome8q11.23
Functionis a microtubule-destabilizing phosphoprotein that plays a critical role in regulating microtubule dynamics, neuronal development, and synaptic plasticity.
Primary ExpressionBrain (cortex, hippocampus), Testis, Lymphocytes
Subcellular Localization</th><td>Cytoplasm, neuronal axons, dendrites, growth cones</td></tr>
Molecular Weight18 kDa
Amino Acids149 aa
Exons6
PathwaysAxonal Transport, Tdp-43
UniProt IDP16949
NCBI Gene ID3925
Ensembl IDENSG00000117682
OMIM151440
GeneCardsSTATHMIN
Human Protein AtlasSTATHMIN
Associated DiseasesAls, Tumor
InteractionsTDP-43, DNA, NEURODEGENERATION, AMYOTROPHIC LATERAL SCLEROSIS, DEMENTIA, RNA
KG Connections82 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Cryptic Exon Silencing Restoration
Score: 0.46

Related Analyses (5)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: activates
Dementia Australia
institution · KG edge: inhibits
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: activates

Knowledge Graph (12 edges)

STATHMIN expressed_in C9ORF72
STATHMIN associated_with ABCB1
STATHMIN regulates STATHMIN-2
STATHMIN interacts_with STATHMIN-2
STATHMIN activates STATHMIN-2
STATHMIN inhibits STATHMIN-2
STATHMIN inhibits TDP-43
STATHMIN regulates Axonal Transport
STATHMIN inhibits Amyotrophic Lateral Sclerosis
STATHMIN regulates Neurodegeneration