gene

NEFL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEFL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

198Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

NEFL is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, interacts with. Associated with ALS, ALZHEIMER'S DISEASE, Als. Connected to 88 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NEFL
Full Name	Neurofilament Light Chain
Chromosome	8p21.2
Function	These dimers associate in an antiparallel, staggered manner to form tetramers, which then laterally associate into protofilaments and mature 10-nm intermediate filaments.
Primary Expression	Motor Neurons, Cortical Neurons, Peripheral Nerves, All Neurons (ubiquitous)
Molecular Weight	62 kDa
Amino Acids	543 aa
Exons	4
Pathways	Axonal Transport
UniProt ID	P07196
NCBI Gene ID	4747
Ensembl ID	ENSG00000277586
OMIM	162280
GeneCards	NEFL
Human Protein Atlas	NEFL
Associated Diseases	Alzheimers_disease
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, BCL2, BNIP3L, C9ORF72, CNR1
SciDEX Hypotheses	Plasma NfL Elevation Secondary to BBB-Associated T Plasma NfL Elevation Secondary to BBB-Associated T
KG Connections	197 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NEFL — AlphaFold P07196 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    TPM2["TPM2"] -->|"binds"| NEFL["NEFL"]
    NEFL["NEFL"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    NEFL["NEFL"] -->|"biomarker for"| Als["Als"]
    NEFL["NEFL"] -->|"biomarker for"| Inflammation["Inflammation"]
    NEFL["NEFL"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    NEFL["NEFL"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    NEFL["NEFL"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    NEFL["NEFL"] -->|"therapeutic target"| Als["Als"]
    NEFL["NEFL"] -->|"interacts with"| Als["Als"]
    NEFL["NEFL"] -->|"interacts with"| Ms["Ms"]
    NEFL["NEFL"] -->|"interacts with"| Amyotrophic_Lateral_Scler["Amyotrophic Lateral Sclerosis"]
    NEFL["NEFL"] -->|"biomarker for"| ALS["ALS"]
    style TPM2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NEFL fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Amyotrophic_Lateral_Scler fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (115)

Target	Relation	Type	Str
NEURODEGENERATIVE DISEASES	involved_in	disease	0.95
Amyotrophic Lateral Sclerosis	involved_in	disease	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
Neurodegeneration	biomarker_for	process	0.85
neurodegeneration	biomarker_for	process	0.82
Alzheimer's disease	biomarker_for	disease	0.80
Als	biomarker_for	disease	0.75
Inflammation	biomarker_for	disease	0.75
Neuroinflammation	biomarker_for	disease	0.75
Alzheimer	biomarker_for	disease	0.75
Neurodegeneration	biomarker_for	disease	0.75
oxidative stress response	participates_in	pathway	0.70
GFAP	biomarker_for	gene	0.70
INFLAMMATION	biomarker_for	gene	0.70
ALZHEIMER	biomarker_for	gene	0.70
ALZHEIMER'S DISEASE	biomarker_for	gene	0.70
NEUROINFLAMMATION	biomarker_for	gene	0.70
Alzheimer	expressed_in	disease	0.65
Dementia	contributes_to	disease	0.65
ALS	regulates	disease	0.65
Als	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
ALS	biomarker_for	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Alzheimers_disease	associated_with	disease	0.64
RANK	interacts_with	gene	0.60
Vegf	biomarker_for	protein	0.60
Rb	biomarker_for	protein	0.60
Rb	regulates	protein	0.60
STATHMIN	interacts_with	gene	0.60
Axonal Transport	regulates	pathway	0.60
TPM3	associated_with	gene	0.60
NPTX1	associated_with	gene	0.60
RBFOX3	associated_with	gene	0.60
Amyloid	biomarker_for	pathway	0.60
Mitochondrial Function	interacts_with	pathway	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
APOE Ε4	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
HUB GENES	associated_with	gene	0.60

Incoming (83)

Source	Relation	Type	Str
H6_NfL	detects_neuroaxonal_injury	biomarker	0.00
OLEA	upregulates	compound	0.80
TPM2	binds	gene	0.80
AMYLOID	associated_with	protein	0.66
ALZHEIMER'S DISEASE	associated_with	disease	0.66
TAU	associated_with	protein	0.66
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
NPTX1	biomarker_for	gene	0.60
CHIT1	biomarker_for	gene	0.60
MDH1	biomarker_for	gene	0.60
PDGFRB	biomarker_for	gene	0.60
SQSTM1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
APOE	biomarker_for	gene	0.60
SYT1	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
TAU	biomarker_for	gene	0.60
MAP1LC3	activates	gene	0.60
VEGFA	biomarker_for	gene	0.60
IL4	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
APOE Ε4	biomarker_for	gene	0.60
FTLD	associated_with	gene	0.60
IL9	biomarker_for	gene	0.60
TPR	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
RGS4	regulates	gene	0.60
AURKB	associated_with	gene	0.60
CALM1	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
PVALB	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
NEFM	regulates	gene	0.60
CNR1	regulates	gene	0.60
TAU	expressed_in	gene	0.60
MKI67	associated_with	gene	0.60
CNP	associated_with	gene	0.60
CCL25	associated_with	gene	0.60
MMP1	associated_with	gene	0.60
MAPT	phosphorylates	gene	0.60
BCL2	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.485	-	What blood-brain barrier permeability ch

Mentioning Analyses (2)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.940

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.745

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

What blood-brain barrier permeability changes serve as early biomarkers for neur

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning NEFL in their description or question text

No additional research found

NEFL

Understanding Entity Pages

Summary

Wiki Pages (3)

NEFL — Neurofilament Light Chain

NEFL Gene

Neurofilament-Light Chain (NEFL) Protein

Pathway Diagram

Outgoing (115)

Incoming (83)

Targeting Hypotheses (2)

Mentioning Analyses (2)

What blood-brain barrier permeability changes serve as early biomarkers for neur

What blood-brain barrier permeability changes serve as early biomarkers for neur

Experiments (0)

Related Papers (0)

Debates (2)

What blood-brain barrier permeability changes serve as early biomarkers for neur

What blood-brain barrier permeability changes serve as early biomarkers for neur

Related Research