protein 842 words KG: SYNAPTOPHYSINPROTEIN
Contents

Synaptophysin Protein

🔬 Protein Info
Gene SymbolSYP
Full NameSynaptophysin
AliasesSYNAPTOPHYSINPROTEIN
ChromosomeXp11.23
FunctionSynaptophysin is the most abundant synaptic vesicle membrane protein, constituting up to 10% of all synaptic vesicle proteins.
Primary ExpressionBrain (cortex, hippocampus), cerebellum, retina, neuroendocrine cells
Molecular Weight38 kDa
Amino Acids316 aa
PathwaysAmyloid, Apoptosis
UniProt IDP21579
Ensembl IDENSG00000100391
GeneCardsSYP
Human Protein AtlasSYP
Length313 amino acids
Molecular weightApproximately 38 kDa
Associated DiseasesALS, Epilepsy, Ms
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ANXIETY, APP
KG Connections309 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (46)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
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Related Analyses (22)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (4)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40

See Also (15)

DALY Methodology — Neurodegeneration
disease · Pages share 41 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 41 hypotheses
Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 41 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 41 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 41 hypotheses

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