protein 653 words KG: TLR2PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

TLR2 Protein — Toll-Like Receptor 2

🔬 Protein Info
Gene SymbolTLR2
Full NameToll-Like Receptor 2
Chromosome4q31.3
Protein TypeReceptor
FunctionTLR2 is expressed in microglia, astrocytes, and neurons throughout the brain.
Primary Expressionmicroglia, astrocytes, and neurons throughout the brain
Amino Acids784 aa
Exons3
PathwaysNF-κB, PI3K
UniProt IDQ9Y257
NCBI Gene ID7103
Ensembl IDENSG00000137462
OMIM603028
GeneCardsTLR2
Human Protein AtlasTLR2
Associated DiseasesALS, Alzheimer, Brain Injury, Fibrosis, Inflammation
Known Drugs/CompoundsC29
InteractionsCMKLR1, RAGE, NFKBIA, MRC1, IL1B, ITGAM
KG Connections702 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (4)

Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85
TLR expression in α-synuclein overexpressing mice
validation · proposed · Score: 0.80
NLRP3 Inflammasome Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in