| Gene Symbol | TNF Receptor Superfamily Member 1A |
| Aliases | TNFRSF1A (TNFR1) |
| Chromosome | 12p13.31 |
| Protein Type | Receptor |
| Function | is a member of the tumor necrosis factor receptor superfamily. |
| Subcellular Localization | </strong> Plasma membrane, endosomes, Golgi apparatus</div> [@decourt2007] |
| Molecular Weight | 55 kDa |
| Amino Acids | 455 aa |
| Exons | 10 |
| Pathways | NF-κB, MAPK pathway |
| UniProt ID | P19438 |
| NCBI Gene ID | 7132 |
| Extracellular domain (ECD) | Contains four cysteine-rich domains (CRDs) that bind TNF-α |
| Transmembrane domain | Single α-helical transmembrane segment |
| Cytoplasmic domain (DD) | Contains the death domain (~70 aa) for signaling |
| Associated Diseases | ALS, Alzheimer, Neurodegeneration, Neuroinflammation, Parkinson |
| Interactions | Actin, ALS, ALZHEIMER, AMYOTROPHIC LATERAL SCLEROSIS, AND, ANXIETY |
| KG Connections | 382 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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