| Gene Symbol | SOD3 |
| Aliases | EC-SOD |
| Chromosome | 4p15.2 |
| Protein Type | Gene |
| Function | is a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1]. |
| Primary Expression | neurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart |
| Molecular Weight | 135 kDa |
| Amino Acids | 366 aa |
| Exons | 5 |
| GeneCards | SOD3 |
| Human Protein Atlas | SOD3 |
| Heparin-binding domain | The C-terminal region contains a heparin-binding motif that localizes the enzyme to cell surfaces and the extracellular matrix [5] |
| Glycosylation | The protein is N-glycosylated, which affects its stability and tissue distribution [6] |
| Extracellular localization | Unlike SOD1 and SOD2, SOD3 functions primarily in the extracellular space [7] |
| Oxidative stress reduction | SOD3 neutralizes extracellular superoxide radicals that contribute to amyloid-beta (Aβ) toxicity and neuronal death [8] |
| Associated Diseases | Amyotrophic Lateral Sclerosis |
| Interactions | APOE, C/EBPβ, ERK1, GSH, HO1, NRF2 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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