gene 1,148 words KG: SOD3
Contents

SOD3 Gene

🧬 Gene Info
Gene SymbolSOD3
Full Namesod3
AliasesEC-SOD
Chromosome4p15.2
Protein TypeGene
Functionis a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1].
Primary Expressionneurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart
Molecular Weight135 kDa
Amino Acids366 aa
Exons5
NCBI Gene IDSearch NCBI
GeneCardsSOD3
Human Protein AtlasSOD3
Associated DiseasesAmyotrophic Lateral Sclerosis
InteractionsERK1, APOE, C/EBPβ, SOD1, SOD2, HO1
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (9)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

erk-mapk-signaling-neurodegeneration
mechanism · KG edge: expressed_in
Angiogenesis Pathway
mechanism · KG edge: protects_against
Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: inhibits
SOD2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SOD3 inhibits ERK1
SOD3 expressed_in NRF2
SOD3 expressed_in SOD1
SOD3 expressed_in SOD2
SOD3 expressed_in EGFR
SOD3 inhibits Diabetes
SOD3 inhibits Fibrosis
SOD3 inhibits Als
SOD3 inhibits Cardiovascular
SOD3 inhibits Inflammation