concept

GSH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

854Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GSH
Key Genes/Proteins	GPX4, NRF2, ROS, ALOX12
Related Pathways	oxidative stress response, ferroptosis, unfolded protein response, apoptosis pathway, pyroptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GSH["GSH"]
    GSH -->|"activates"| GPX4["GPX4"]
    GSH -->|"involved_in"| Redox_Homeostasis["Redox Homeostasis"]
    GSH -->|"expressed in"| Retinal_Ganglion_Cell["Retinal Ganglion Cell"]
    GSH -->|"activates"| ROS["ROS"]
    GSH -->|"inhibits"| NEURON["NEURON"]
    GSH -->|"activates"| SLC7A11["SLC7A11"]
    GSH -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| GSH
    NRF2["NRF2"] -->|"regulates"| GSH
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GSH
    GPX4 -->|"inhibits"| GSH
    CATALASE["CATALASE"] -->|"interacts"| GSH
    GLIOSIS["GLIOSIS"] -->|"activates"| GSH
    ACSL4["ACSL4"] -->|"activates"| GSH

Outgoing (514)

Target	Relation	Type	Str
GPX4	activates	protein	0.90
oxidative stress response	participates_in	pathway	0.90
ferroptosis	participates_in	pathway	0.90
neurons	expressed_in	cell_type	0.80
ferroptosis	activates	process	0.80
unfolded protein response	participates_in	pathway	0.80
ROS	inhibits	gene	0.80
apoptosis pathway	participates_in	pathway	0.70
pyroptosis	participates_in	pathway	0.70
hippocampus	expressed_in	brain_region	0.70
neurons	activates	cell_type	0.70
neurons	regulates	cell_type	0.70
ROS	activates	protein	0.65
Ischemia	inhibits	disease	0.65
Cancer	activates	disease	0.65
Ischemia	activates	disease	0.65
Diabetes	inhibits	disease	0.65
ALS	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Glaucoma	causes	disease	0.65
Hypertension	inhibits	disease	0.65
Inflammation	causes	disease	0.65
Als	therapeutic_target	disease	0.65
Pyroptosis	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Als	inhibits	disease	0.65
Obesity	activates	disease	0.65
Depression	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Als	protects_against	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Pyroptosis	biomarker_for	disease	0.65
Ferroptosis	biomarker_for	disease	0.65
Huntington	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Ferroptosis	associated_with	disease	0.65
Tumor	activates	disease	0.65

Incoming (340)

Source	Relation	Type	Str
NRF2	upregulates	protein	0.90
FERROPTOSIS	activates	process	0.80
CAT	associated_with	gene	0.80
ALOX12	expressed_in	gene	0.70
NRF2	regulates	protein	0.64
NRF2	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
GPX4	activates	gene	0.60
AND	inhibits	gene	0.60
ALOX15	activates	gene	0.60
GENES	activates	gene	0.60
HMOX1	activates	gene	0.60
RNA	activates	gene	0.60
NFE2L2	activates	gene	0.60
ALOXE3	activates	gene	0.60
NRF2	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
HO-1	inhibits	gene	0.60
CATALASE	stabilizes	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
AND	stabilizes	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
IL-6	inhibits	gene	0.60
NQO1	inhibits	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
NAD	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
ALOX12	activates	gene	0.60
ALOX5	activates	gene	0.60
VDR	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
ATG7	activates	gene	0.60
ROS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
GASDERMIN	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	activates	gene	0.60
GSDMD	activates	gene	0.60
P53	activates	gene	0.60
DEPRESSION	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FTH1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSH

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

CBS/PSP Supplements Guide

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

oxidative-stress-comparison

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

Ferroptosis in Alzheimer's Disease

metal-ion-synuclein-mitochondria-axis-parkinsons

NACET (N-Acetylcysteine Ethyl Ester)

Curcumin for Neurodegeneration

Lipid Peroxidation in Neurodegeneration

Metabolomic Alterations in PSP

Quinolinic Acid Neurotoxicity in Neurodegeneration

Ferroptosis in Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

msa-pathophysiology-disease-mechanisms