concept

HO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	Heme Oxygenase-1 (HO-1)
Summary	HO-1 is an inducible enzyme degrading heme into biliverdin, CO, and iron. Critical cytoprotective enzyme in oxidative stress and neuroinflammation. Therapeutic target for AD, PD, and ALS.
Key Genes/Proteins	NFE2L2, NRF2
Related Diseases	Addiction, Dementia, Alzheimer, Inflammation, Depression

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HO1["HO1"]
    HO1 -->|"regulates"| Alzheimer["Alzheimer"]
    HO1 -->|"target for"| Addiction["Addiction"]
    HO1 -->|"target for"| Depression["Depression"]
    HO1 -->|"target for"| Stroke["Stroke"]
    HO1 -->|"target for"| Parkinson["Parkinson"]
    HO1 -->|"target for"| Epilepsy["Epilepsy"]
    HO1 -->|"target for"| Anxiety["Anxiety"]
    Ric["Ric"] -->|"upregulates"| HO1
    NFE2L2["NFE2L2"] -->|"regulates"| HO1
    NRF2["NRF2"] -->|"activates"| HO1
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| HO1
    MICROGLIA["MICROGLIA"] -->|"regulates"| HO1

Outgoing (80)

Target	Relation	Type	Str
Addiction	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Depression	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Anxiety	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
NRF2	associated_with	gene	0.60
ARG1	associated_with	gene	0.60
NRF2	therapeutic_target	gene	0.60
PKC	therapeutic_target	gene	0.60
BDNF	associated_with	gene	0.60
STAT6	associated_with	gene	0.60
REELIN	associated_with	gene	0.60
NQO1	associated_with	gene	0.60
NRF2	inhibits	gene	0.60
NRF2	biomarker_for	gene	0.60
NRF2	activates	gene	0.60
DMT1	regulates	gene	0.60
NQO1	activates	gene	0.60
AIM2	regulates	gene	0.60
P2RY1	associated_with	gene	0.60
PON1	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
SOD3	activates	gene	0.60
IL6	biomarker_for	gene	0.60
LRP1	biomarker_for	gene	0.60
SLC40A1	biomarker_for	gene	0.60
SLC7A11	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
ferroptosis	participates_in	pathway	0.60
SLC40A1	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
AND	associated_with	gene	0.60
GSH	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60

Incoming (27)

Source	Relation	Type	Str
Ric	upregulates	process	0.92
NFE2L2	regulates	gene	0.90
NRF2	activates	protein	0.90
NFE2L2	upregulates	gene	0.85
NRF2	upregulates	gene	0.80
NRF2	associated_with	gene	0.60
ARG1	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
FSP1	regulates	gene	0.60
GPX4	regulates	gene	0.60
ALOX12	associated_with	gene	0.60
AR	associated_with	gene	0.60
ACSL4	biomarker_for	gene	0.60
CD163	biomarker_for	gene	0.60
CD206	biomarker_for	gene	0.60
CD36	biomarker_for	gene	0.60
GPX4	biomarker_for	gene	0.60
GFAP	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
GSH	associated_with	gene	0.60
GSH	biomarker_for	gene	0.60
GSH	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HO1

Understanding Entity Pages

Wiki Pages (7)

Heme Oxygenase-1 (HO-1)

heme-oxygenase-1-protein

carbon-monoxide-therapy-neurodegeneration

Beclin 1 (BECN1)

BECN1 Protein