Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ATOX1 |
| Full Name | Antioxidant Protein 1 (Copper Chaperone) |
| Aliases | Page for ATOX1 |
| Chromosome | 5q31.2 |
| Protein Type | Chaperone |
| Function | ATOX1 encodes a copper chaperone protein that plays a critical role in copper homeostasis. |
| Primary Expression | most tissues, with highest expression in: |
| Molecular Weight | 9 kDa |
| Amino Acids | 68 aa |
| Pathways | Mitophagy, Oxidative Stress |
| UniProt ID | O00244 |
| NCBI Gene ID | 475 |
| Ensembl ID | ENSG00000137871 |
| GeneCards | ATOX1 |
| Human Protein Atlas | ATOX1 |
| Associated Diseases | Cancer, Hepatocellular Carcinoma |
| Interactions | DJ-1 |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATOX1["ATOX1"]
Copper_Homeostasis["Copper Homeostasis"]
ATOX1 -->|"regulates"| Copper_Homeostasis
PRRX2["PRRX2"]
PRRX2 -->|"upregulates"| ATOX1
MDC1["MDC1"]
ATOX1 -->|"upregulates"| MDC1
NCF1["NCF1"]
ATOX1 -->|"upregulates"| NCF1
PPA2["PPA2"]
ATOX1 -->|"upregulates"| PPA2
SOD3["SOD3"]
ATOX1 -->|"upregulates"| SOD3
Cancer{"Cancer"}
ATOX1 -->|"associated_with"| Cancer
Cell_Proliferation["Cell Proliferation"]
ATOX1 -->|"associated_with"| Cell_Proliferation
Cell_Invasion["Cell Invasion"]
ATOX1 -->|"associated_with"| Cell_Invasion
Cuproptosis["Cuproptosis"]
ATOX1 -->|"associated_with"| Cuproptosis
Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
ATOX1 -->|"causes"| Mitochondrial_Dysfunction
Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
ATOX1 -->|"associated_with"| Hepatocellular_Carcinoma
Copper_Toxicity["Copper Toxicity"]
ATOX1 -->|"associated_with"| Copper_Toxicity
Mitochondrial_Function["Mitochondrial Function"]
ATOX1 -->|"associated_with"| Mitochondrial_Function
MAPK_Signaling(["MAPK Signaling"])
ATOX1 -->|"activates"| MAPK_Signaling| Target | Relation | Type | Str |
|---|---|---|---|
| Copper Homeostasis | regulates | biological_process | 0.90 |
| MDC1 | upregulates | gene | 0.80 |
| NCF1 | upregulates | gene | 0.80 |
| PPA2 | upregulates | gene | 0.80 |
| SOD3 | upregulates | gene | 0.80 |
| Cell Proliferation | associated_with | biological_process | 0.80 |
| Cell Invasion | associated_with | biological_process | 0.80 |
| Cuproptosis | associated_with | biological_process | 0.80 |
| Copper Toxicity | associated_with | biological_process | 0.80 |
| MAPK Signaling | activates | pathway | 0.80 |
| Cancer | associated_with | disease | 0.80 |
| Hepatocellular Carcinoma | associated_with | disease | 0.80 |
| oxidative stress | protects_against | process | 0.80 |
| Traumatic Brain Injury | regulates | disease | 0.65 |
| DJ-1 | interacts_with | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| MITOPHAGY | regulates | gene | 0.60 |
| Actin | regulates | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| oxidative stress | associated_with | process | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| DJ-1 | regulates | protein | 0.50 |
| mitophagy | regulates | pathway | 0.50 |
| oxidative stress | regulates | phenotype | 0.50 |
| BRAIN INJURY | regulates | concept | 0.50 |
| NEURONS | regulates | concept | 0.50 |
| Chaperone | regulates | pathway | 0.50 |
| oxidative stress | inhibits | phenotype | 0.50 |
| oxidative stress | expressed_in | phenotype | 0.50 |
| DJ-1 | inhibits | protein | 0.50 |
| oxidative stress | co_mentioned | process | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PRRX2 | upregulates | transcription_factor | 0.90 |
| MITOPHAGY | regulates | gene | 0.60 |
| BRAIN INJURY | regulates | gene | 0.60 |
| OXIDATIVE STRESS | regulates | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| DJ-1 | interacts_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| MITOCHONDRIA | expressed_in | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||