protein 1,600 words KG: TMEM106B
Contents

TMEM106B

🔬 Protein Info
Gene SymbolTMEM106B
AliasesTransmembrane Protein 106B
Chromosome7p21.3
Protein FamilyType II lysosomal transmembrane protein family
Functionis a 323-amino acid type II lysosomal transmembrane protein encoded by the TMEM106B gene on chromosome 7p21.
Primary ExpressionLate endosomes and lysosomes
Molecular Weight30.3 kDa
Amino Acids274 aa
Exons9
PathwaysAutophagy, endosome-lysosome function
UniProt IDQ9NUM4
GeneCardsTMEM106B
Human Protein AtlasTMEM106B
Molecular weightApproximately 31 kDa
TopologyType II transmembrane protein (N-out, C-in)
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, APOE,
KG Connections378 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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UniProtWikipedia

Knowledge Graph (12 edges)

TMEM106B regulates endosome-lysosome function
TREM2 associated_with TMEM106B
TMEM106B associated_with SIGLEC9
TMEM106B associated_with SIRPA
TMEM106B associated_with GRN
MAPT associated_with TMEM106B
TMEM106B associated_with C9ORF72
TMEM106B interacts_with NFL
SIGLEC9 associated_with TMEM106B
TMEM106B associated_with CTSH

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