gene 2,748 words KG: SIGLEC9 2026-03-24
kind:genesection:genesstate:published
Contents

SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

🧬 Gene Info
Gene SymbolSIGLEC9
Full NameSialic Acid Binding Ig-Like Lectin 9
Chromosome19q13.4
Functionis a member of the CD33-related Siglec family of inhibitory lectins.
Primary ExpressionNeutrophils, monocytes, NK cells, B cells
Molecular Weight~55 kDa
Amino Acids482 aa
Exons11
UniProt IDQ9Y736
NCBI Gene ID27180
GeneCardsSIGLEC9
Human Protein AtlasSIGLEC9
FeatureValue
Genomic Coordinateschr19:50,761,328-50,778,310 (GRCh38)
Exon Count11
Associated DiseasesALS, Alzheimer's disease, Parkinson's disease, Tumor
InteractionsSIRPA, TPP1, VEGFB, C1R, C1S, CLN5
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.49
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.44

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: therapeutic_target
Dementia Australia
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: therapeutic_target
TMEM106B Lysosomal Restoration Therapy for Neurodegener
general · KG edge: associated_with
SIRPA Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SIGLEC9 associated_with SIRPA
SIGLEC9 associated_with GRN
SIGLEC9 therapeutic_target GBM
SIGLEC9 associated_with TMEM106B
SIGLEC9 associated_with CTSH
SIGLEC9 interacts_with SIRPA
SIGLEC9 interacts_with TPP1
SIGLEC9 interacts_with VEGFB
SIGLEC9 therapeutic_target Alzheimer
SIGLEC9 therapeutic_target Ms