gene 649 words KG: CTSH 2026-03-24
kind:genesection:genesstate:published
Contents

CTSH Gene

🧬 Gene Info
Gene SymbolCTSH
Chromosome15q25.1 [@hook2018]
Protein TypeProtease
Functionis a gene involved in cellular processes relevant to neurodegeneration.
Primary Expressionvarious tissues:
Molecular Weight37 kDa
Amino Acids253 aa
Pathwayssignaling:** Regulation of growth factors
UniProt IDP09668
NCBI Gene ID1515
Ensembl IDENSG00000103852
GeneCardsCTSH
Human Protein AtlasCTSH
PathwayRole
Lysosomal DegradationProtein turnover in neurons
Associated DiseasesAlzheimer, Dementia, Ms
InteractionsC1QB, SOD1, HSP27, LRP1, TAU, TREM2
KG Connections174 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSH interacts_with C1QB
CTSH activates SOD1
CTSH interacts_with HSP27
CTSH associated_with PILRB
CTSH associated_with GBA
CTSH associated_with CR1
CTSH associated_with TMEM106B
CTSH associated_with SIGLEC9
CTSH associated_with SIRPA
CTSH associated_with GRN