biomarker 1,419 words KG: NFL 2026-03-24
kind:biomarkersection:biomarkersstate:published
Contents

Neurofilament Light Chain (NfL) in Blood - Biomarker

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
FunctionThese dimers associate in an antiparallel, staggered manner to form tetramers, which then laterally associate into protofilaments and mature 10-nm intermediate filaments.
Primary ExpressionMotor Neurons, Cortical Neurons, Peripheral Nerves, All Neurons (ubiquitous)
Molecular Weight~61 kDa (native), ~10 kDa (fragments in blood)
Amino Acids543 aa
Exons4
PathwaysAxonal Transport
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000277586
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAlzheimers_disease
InteractionsSTMN2, PVALB, RANK, CNR1, STATHMIN, NRGN
KG Connections200 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.77
Microbial Inflammasome Priming Prevention
Score: 0.72
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Vagal Afferent Microbial Signal Modulation
Score: 0.66

Related Analyses (10)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
TLR expression analysis in Parkinson's disease patients
clinical · proposed · Score: 0.85

See Also (4)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with

Knowledge Graph (12 edges)

NFL interacts_with GFAP
NFL biomarker_for GFAP
NFL associated_with GFAP
NFL interacts_with TMEM119
NFL interacts_with UCHL1
NFL biomarker_for SYNAPTOPHYSIN
NFL interacts_with UBIQUITIN
NFL biomarker_for BACE1
NFL biomarker_for NEUROGRANIN
NFL biomarker_for TAU

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