concept

TRIM34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

34Outgoing

3Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TRIM34
Key Genes/Proteins	UPF1, GPX4
Related Diseases	Ferroptosis Resistance, Hepatocellular Carcinoma, Cell Proliferation, Cell Migration, Cell Invasion

Pathway Diagram

graph TD
    TRIM34["TRIM34"]
    TRIM34 -->|"inhibits"| Ferroptosis["Ferroptosis"]
    TRIM34 -->|"interacts"| UPF1["UPF1"]
    TRIM34 -->|"upregulates"| GPX4["GPX4"]
    TRIM34 -->|"correlates_with"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    TRIM34 -->|"target for"| Cancer["Cancer"]
    TRIM34 -->|"activates"| Als["Als"]
    TRIM34 -->|"activates"| ALS["ALS"]
    GPX4 -->|"activates"| TRIM34
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| TRIM34

Outgoing (34)

Target	Relation	Type	Str
Ferroptosis	inhibits	process	0.95
Ferroptosis	suppresses	process	0.95
Ferroptosis Resistance	mediates	phenotype	0.95
UPF1	promotes	protein	0.93
UPF1	interacts_with	protein	0.92
GPX4	upregulates	protein	0.90
Hepatocellular Carcinoma	biomarker_for	disease	0.90
Cell Proliferation	promotes	phenotype	0.90
Cell Migration	promotes	phenotype	0.90
Cell Invasion	promotes	phenotype	0.90
UPF1	associated_with	protein	0.88
Anti-Pd-1 Immunotherapy	modulates	drug	0.85
Ferroptosis	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Immune Response	therapeutic_target	pathway	0.60
PD-1	associated_with	gene	0.60
GPX4	activates	gene	0.60
AND	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
Ubiquitin	degrades	protein	0.60
Ras	activates	protein	0.60
CRISPR-Cas	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ferroptosis	activates	process	0.60
ferroptosis	associated_with	process	0.60

Incoming (3)

Source	Relation	Type	Str
FERROPTOSIS	regulates	process	0.90
GPX4	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found