concept

PD-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PD-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

260Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PD-1
Key Genes/Proteins	PD-L1, LKB1, NFAT, BCL2L1
Related Diseases	brain metastases, Cancer, ALS, Carcinoma, Tumor
Related Pathways	T Cell Activation

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PD_1["PD-1"]
    style PD_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PD_1 -.->|"inhibits"| PD_L1([PD-L1])
    PD_1 -->|"activates"| Mitophagy["Mitophagy"]
    PD_1 -.->|"downregulates"| BCL2L1([BCL2L1])
    PD_1 -.->|"inhibits"| T_Cell_Activation["T Cell Activation"]
    PD_1 -.->|"inhibits"| CT_26_Tumor["CT-26 Tumor"]
    PD_1 -.->|"inhibits"| Cancer["Cancer"]
    PD_1 -.->|"inhibits"| ALS["ALS"]
    PD_1 -.->|"inhibits"| Carcinoma["Carcinoma"]
    PD_1 -->|"activates"| Tumor["Tumor"]
    LKB1([LKB1]) -->|"regulates"| PD_1
    PD_L1 -->|"binds"| PD_1
    Nivolumab{"Nivolumab"} -->|"targets"| PD_1
    Pembrolizumab{"Pembrolizumab"} -->|"targets"| PD_1
    NFAT([NFAT]) -->|"upregulates"| PD_1
    WNT([WNT]) -.->|"inhibits"| PD_1
    LZTR1([LZTR1]) -.->|"inhibits"| PD_1
    SF3B1([SF3B1]) -.->|"inhibits"| PD_1
    APOB([APOB]) -.->|"inhibits"| PD_1

Outgoing (153)

Target	Relation	Type	Str
PD-L1	inhibits	gene	0.95
T cell exhaustion	promotes	process	0.90
Mitophagy	activates	process	0.85
BCL2L1	downregulates	gene	0.82
T Cell Activation	inhibits	biological_process	0.70
PD-L1	activates	gene	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Obesity	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Glioblastoma	associated_with	disease	0.65
Glioblastoma	inhibits	disease	0.65
VEGFA	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
MET	inhibits	gene	0.60
Dna Methylation	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
TCR	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
EOMES	activates	gene	0.60
Immune Response	activates	pathway	0.60
RNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
VIRAL INFECTIONS	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
PRDM1	inhibits	gene	0.60
LRP1	activates	gene	0.60
DLL4	activates	gene	0.60
NOTCH	activates	gene	0.60
Notch	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60

Incoming (107)

Source	Relation	Type	Str
LKB1	regulates	gene	0.95
NFAT	upregulates	protein	0.88
brain metastases	associated_with	disease	0.70
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
APOB	inhibits	gene	0.60
EEF1A1	inhibits	gene	0.60
P53	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
TERT	inhibits	gene	0.60
JUN	inhibits	gene	0.60
AND	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
GENES	inhibits	gene	0.60
DNA	inhibits	gene	0.60
PD-L1	activates	gene	0.60
CD8	inhibits	gene	0.60
MAF	inhibits	gene	0.60
CD4	inhibits	gene	0.60
CCL2	activates	gene	0.60
NOTCH2	activates	gene	0.60
MCL1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
LZTR1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
ANGPT1	activates	gene	0.60
STING	inhibits	gene	0.60
PDGFRB	activates	gene	0.60
PRDM1	inhibits	gene	0.60
EOMES	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
GBM	regulates	gene	0.60
OMA1	regulates	gene	0.60
HSPA9	activates	gene	0.60
DNA	activates	gene	0.60
CGAS-STING	activates	gene	0.60
LKB1	expressed_in	gene	0.60
SCD1	activates	gene	0.60
HMGCR	activates	gene	0.60
FASN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PD-1

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

NPM1 Gene

nct07165106

Synaptic Vesicle Trafficking in Parkinson's Disease

metal-ion-synuclein-mitochondria-axis-parkinsons

proteasome-ubiquitin-system-dysfunction-parkinsons

sporadic-familial-pd-comparison

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

Orexin Neurons

Aurobindo Pharma Ltd.

PTCH2 Gene

transcranial-sonography-cbs-psp

PICK1 - Protein Interacting With C Kinase 1

SNX3 Protein — Sorting Nexin 3 in Neurodegeneration

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

nct06365190-rtms-pd

Non-Dopaminergic Neurotransmitter Degeneration as Upstream Driver in Parkinson's Disease

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain