Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VWF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | VWF |
| Pathways | Angiogenesis, Bone Metabolism, Hemostasis, Inflammation, Vwf Biosynthesis |
| GeneCards | VWF |
| Human Protein Atlas | VWF |
| Associated Diseases | Alzheimer |
| Interactions | FACTOR VIII, Factor VIII, Collagen |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
VWF["VWF"] -->|"interacts"| FACTOR_VIII["FACTOR VIII"]
style FACTOR_VIII fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
VWF["VWF"] -->|"interacts"| Platelets["Platelets"]
style Platelets fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
VWF["VWF"] -->|"interacts"| Collagen["Collagen"]
style Collagen fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
VWF["VWF"] -->|"regulates"| Hemostasis["Hemostasis"]
style Hemostasis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VWF["VWF"] -->|"regulates"| Bone_Metabolism["Bone Metabolism"]
style Bone_Metabolism fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VWF["VWF"] -->|"regulates"| Angiogenesis["Angiogenesis"]
style Angiogenesis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
VWF["VWF"] -->|"contributes to"| Malaria["Malaria"]
style Malaria fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style VWF fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| FACTOR VIII | interacts_with | protein | 0.95 |
| Platelets | interacts_with | cell_type | 0.95 |
| Factor VIII | interacts_with | protein | 0.95 |
| Collagen | interacts_with | protein | 0.95 |
| Hemostasis | regulates | process | 0.95 |
| Bone Metabolism | regulates | process | 0.85 |
| Vwf Biosynthesis | involved_in | process | 0.85 |
| Vwf Proteolysis | involved_in | process | 0.85 |
| Vwf Clearance | involved_in | process | 0.85 |
| Angiogenesis | regulates | process | 0.80 |
| Malaria | contributes_to | disease | 0.80 |
| Sickle Cell Disease | contributes_to | disease | 0.80 |
| Wound Healing | regulates | process | 0.78 |
| Inflammation | regulates | process | 0.78 |
| Sepsis | contributes_to | disease | 0.75 |
| Liver Disease | contributes_to | disease | 0.72 |
| Alzheimer | associated_with | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||