protein

Collagen

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Collagen: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	Collagen
Associated Diseases	Cerebral Amyloid Angiopathy, Senescence
Interactions	VWF, NRF2, STROKE, AMPK, CD68, CX3CR1
KG Connections	215 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Collagen["Collagen"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -->|"activates"| Stroke["Stroke"]
    style Stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -->|"expressed in"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
    style Ferroptosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -->|"activates"| Fibrosis["Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Collagen["Collagen"] -->|"encodes"| Glioblastoma["Glioblastoma"]
    style Glioblastoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    VWF["VWF"] -->|"interacts"| Collagen["Collagen"]
    style VWF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MMP1["MMP1"] -->|"degrades"| Collagen["Collagen"]
    style MMP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NRF2["NRF2"] -->|"activates"| Collagen["Collagen"]
    style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    STROKE["STROKE"] -->|"activates"| Collagen["Collagen"]
    style STROKE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AMPK["AMPK"] -->|"activates"| Collagen["Collagen"]
    style AMPK fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Collagen fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (67)

Target	Relation	Type	Str
Neuroinflammation	activates	disease	0.60
Stroke	activates	disease	0.60
Cancer	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Ferroptosis	inhibits	disease	0.60
Als	activates	disease	0.60
Als	regulates	disease	0.60
Fibrosis	activates	disease	0.60
Glioblastoma	encodes	disease	0.60
Aging	activates	disease	0.60
Fibrosis	inhibits	disease	0.60
Als	inhibits	disease	0.60
Pyroptosis	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Aging	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Hypertension	therapeutic_target	disease	0.60
Stroke	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Aging	expressed_in	disease	0.60
Cancer	activates	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Anxiety	activates	disease	0.60
Alzheimer	activates	disease	0.60
Alzheimer	expressed_in	disease	0.60
Senescence	activates	disease	0.60
Glioblastoma	therapeutic_target	disease	0.60
Cerebral Amyloid Angiopathy	associated_with	disease	0.60
Senescence	associated_with	disease	0.60
Aging	interacts_with	disease	0.60
Diabetes	activates	disease	0.60
Anxiety	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Wnt	regulates	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Blood-Brain Barrier	encodes	pathway	0.55
Nf-Κb	inhibits	pathway	0.55
Autophagy	activates	pathway	0.55
Cell Cycle	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Nf-Κb	activates	pathway	0.55
Wnt	expressed_in	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Blood-Brain Barrier	activates	pathway	0.55
Lipid Metabolism	activates	pathway	0.55
Nf-Kb	activates	pathway	0.55
Cholesterol	activates	pathway	0.55
Nf-Κb	expressed_in	pathway	0.55

Incoming (149)

Source	Relation	Type	Str
VWF	interacts_with	protein	0.95
MMP1	degrades	gene	0.80
NRF2	activates	gene	0.60
STROKE	activates	gene	0.60
AMPK	activates	gene	0.60
CD68	activates	gene	0.60
CX3CR1	activates	gene	0.60
CD36	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PPAR	activates	gene	0.60
TNF	activates	gene	0.60
IL-1	activates	gene	0.60
CD163	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
LOX/LOXL1-4	therapeutic_target	gene	0.60
LOXL3	therapeutic_target	gene	0.60
MMP1	activates	gene	0.60
GPX4	inhibits	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
SOX9	activates	gene	0.60
ROS	activates	gene	0.60
MMP3	activates	gene	0.60
ATF4	regulates	gene	0.60
WNT	regulates	gene	0.60
RANKL	regulates	gene	0.60
RANK	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
RUNX2	regulates	gene	0.60
STAT3	activates	gene	0.60
PDGFRB	activates	gene	0.60
NOS3	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
P53	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
RNA	encodes	gene	0.60
GLIOBLASTOMA	encodes	gene	0.60
LOXL2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Collagen

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

williams-syndrome

Blood-Brain Barrier Dysfunction in Neurodegeneration

CNTN6 — Contactin 6

Vascular Cognitive Impairment (VCI)

blood-brain-barrier

CNTN3 — Contactin 3

Cerebral Small Vessel Disease

neurovascular-dysfunction

iron-calcium-glymphatic-convergence-alzheimers

TGF-β Signaling in Parkinson's Disease

Amyloid Precursor Protein (APP)

blood-brain-barrier-endothelial-cells

Choroid-Plexus-in-Alzheimers-Disease

Complement System in Neurodegeneration

TEAD1 — TEA Domain Transcription Factor 1

CTS Gene - Cathepsin S

Safety and Clinical Outcomes Study: Amniotic and Umbilical Cord Tissue Admini... (NCT03899298)