gene

TXN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

132Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

TXN is a gene implicated in neurodegeneration research. Key relationships include: regulates, biomarker for, associated with. Associated with Als, Ms, Sepsis. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolTXN
Full NameTXN — Thioredoxin
Chromosome9q31.3
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionreactive astrocytes - Oligodendrocytes: Important for myelin maintenance - Microglia: Upregulated i
Molecular Weight12 kDa
PathwaysNF-ÎșB
UniProt IDP10599
NCBI Gene ID7295
Ensembl IDENSG00000136810
GeneCardsTXN
Human Protein AtlasTXN
Associated DiseasesALS, Alzheimer
InteractionsSLC2A1, MEF2C, NRF2, SLC6A1, LRRK2, GJA1
KG Connections132 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TXN — AlphaFold P10599 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

TXN — Thioredoxin

gene · 618 words
→

PRDX2 — Peroxiredoxin 2

gene · 3179 words
→

PRDX1 (Peroxiredoxin 1)

protein · 2419 words
→

Nrf2 Signaling in Neurodegeneration

mechanism · 2143 words
→

SLC6A1 Gene

gene · 1651 words
→

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

protein · 1453 words
→

Pathway Diagram

graph TD
    TXN["<b>TXN</b>"]
    Als{"Als"}
    TXN -->|"expressed in"| Als
    Ms{"Ms"}
    TXN -->|"expressed in"| Ms
    TXN -->|"biomarker for"| Ms
    AP2B1["AP2B1"]
    TXN -->|"associated with"| AP2B1
    GRB2["GRB2"]
    TXN -->|"associated with"| GRB2
    PRDX2["PRDX2"]
    TXN -->|"associated with"| PRDX2
    PIK3C3["PIK3C3"]
    TXN -->|"associated with"| PIK3C3
    Ferroptosis(["Ferroptosis"])
    TXN -->|"biomarker for"| Ferroptosis
    MICRORNAS["MICRORNAS"]
    TXN -->|"regulates"| MICRORNAS
    APOPTOSIS["APOPTOSIS"]
    TXN -->|"therapeutic target"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    TXN -->|"therapeutic target"| Apoptosis
    neurodegeneration["neurodegeneration"]
    TXN -->|"implicated in"| neurodegeneration
    NR3C1["NR3C1"]
    NR3C1 -->|"associated with"| TXN
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"biomarker for"| TXN
    ATM["ATM"]
    ATM -->|"interacts with"| TXN
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| TXN
    G6PD["G6PD"]
    G6PD -->|"therapeutic target"| TXN
    style TXN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

TargetRelationTypeStr
Alsexpressed_indisease0.65
Msexpressed_indisease0.65
Msbiomarker_fordisease0.65
Alsbiomarker_fordisease0.65
Sepsisregulatesdisease0.65

Incoming (64)

SourceRelationTypeStr
NR3C1associated_withgene0.60
ATMinteracts_withgene0.60
LPLinteracts_withgene0.60
CALM1interacts_withgene0.60
SLC6A1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found