Entity Detail â Knowledge Graph Node
This page aggregates everything SciDEX knows about TXN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TXN is a gene implicated in neurodegeneration research. Key relationships include: regulates, biomarker for, associated with. Associated with Als, Ms, Sepsis. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | TXN |
| Full Name | TXN â Thioredoxin |
| Chromosome | 9q31.3 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | reactive astrocytes - Oligodendrocytes: Important for myelin maintenance - Microglia: Upregulated i |
| Molecular Weight | 12 kDa |
| Pathways | NF-ÎșB |
| UniProt ID | P10599 |
| NCBI Gene ID | 7295 |
| Ensembl ID | ENSG00000136810 |
| GeneCards | TXN |
| Human Protein Atlas | TXN |
| Associated Diseases | ALS, Alzheimer |
| Interactions | SLC2A1, MEF2C, NRF2, SLC6A1, LRRK2, GJA1 |
| KG Connections | 132 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TXN["<b>TXN</b>"]
Als{"Als"}
TXN -->|"expressed in"| Als
Ms{"Ms"}
TXN -->|"expressed in"| Ms
TXN -->|"biomarker for"| Ms
AP2B1["AP2B1"]
TXN -->|"associated with"| AP2B1
GRB2["GRB2"]
TXN -->|"associated with"| GRB2
PRDX2["PRDX2"]
TXN -->|"associated with"| PRDX2
PIK3C3["PIK3C3"]
TXN -->|"associated with"| PIK3C3
Ferroptosis(["Ferroptosis"])
TXN -->|"biomarker for"| Ferroptosis
MICRORNAS["MICRORNAS"]
TXN -->|"regulates"| MICRORNAS
APOPTOSIS["APOPTOSIS"]
TXN -->|"therapeutic target"| APOPTOSIS
Apoptosis(["Apoptosis"])
TXN -->|"therapeutic target"| Apoptosis
neurodegeneration["neurodegeneration"]
TXN -->|"implicated in"| neurodegeneration
NR3C1["NR3C1"]
NR3C1 -->|"associated with"| TXN
FERROPTOSIS["FERROPTOSIS"]
FERROPTOSIS -->|"biomarker for"| TXN
ATM["ATM"]
ATM -->|"interacts with"| TXN
MIRNAS["MIRNAS"]
MIRNAS -->|"regulates"| TXN
G6PD["G6PD"]
G6PD -->|"therapeutic target"| TXN
style TXN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Sepsis | regulates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Diabetes | expressed_in | disease | 0.65 |
| AP2B1 | associated_with | gene | 0.60 |
| GRB2 | associated_with | gene | 0.60 |
| PRDX2 | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| MAPK14 | regulates | gene | 0.60 |
| BCL2 | regulates | gene | 0.60 |
| SLC2A1 | activates | gene | 0.60 |
| MEF2C | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| SLC6A1 | interacts_with | gene | 0.60 |
| Synaptic Vesicle | expressed_in | pathway | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| GJA1 | interacts_with | gene | 0.60 |
| LPL | interacts_with | gene | 0.60 |
| CALM1 | interacts_with | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| Rb | activates | protein | 0.60 |
| VCP | activates | gene | 0.60 |
| Ferroptosis | biomarker_for | pathway | 0.60 |
| MICRORNAS | regulates | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| OXIDATIVE STRESS | implicated_in | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| IMMUNE INFILTRATION | biomarker_for | gene | 0.60 |
| Oxidative Stress | implicated_in | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
| KRAS | activates | gene | 0.60 |
| EXERCISE | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NR3C1 | associated_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| LPL | interacts_with | gene | 0.60 |
| CALM1 | interacts_with | gene | 0.60 |
| SLC6A1 | interacts_with | gene | 0.60 |
| GJA1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| SLC2A1 | activates | gene | 0.60 |
| MEF2C | activates | gene | 0.60 |
| AMBRA1 | activates | gene | 0.60 |
| BAK1 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| CASP1 | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| CNP | activates | gene | 0.60 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| FUNDC1 | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| GSR | activates | gene | 0.60 |
| HIF1A | activates | gene | 0.60 |
| HUWE1 | activates | gene | 0.60 |
| IL1B | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MUL1 | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| OPA1 | activates | gene | 0.60 |
| PARL | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| FERROPTOSIS | biomarker_for | gene | 0.60 |
| MIRNAS | regulates | gene | 0.60 |
| G6PD | therapeutic_target | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| EXERCISE | activates | gene | 0.60 |
| KRAS | activates | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||