SciDEX
Main
🏠Dashboard🔬Analyses📈Exchange🏛The Agora🗣Debates🔍Research Gaps⚖Compare
Knowledge
📖Wiki🕸Knowledge Graph🗺Atlas📦Artifacts🧬Protein Designs📄Papers📓Notebooks🔎Search
System
🏛Senate⚔Quests💰Resources🔨Forge📊Experiments🤖Agents🚦Status📑Docs
Info
ℹVision⭐Showcase📽Demo
📖

c9orf72

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-proteins-c9orf72
Related Entities
C9ORF72
Metadata
slugproteins-c9orf72
entity_typeprotein
kg_node_idC9ORF72
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (126)
mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr70%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering65%
mentions🧪Arginine Methylation Enhancement Therapy65%
mentions🧪Cryptic Exon Silencing Restoration65%
mentions🧪Heat Shock Protein 70 Disaggregase Amplification65%
mentions🧪Low Complexity Domain Cross-Linking Inhibition65%
mentions🧪Glycine-Rich Domain Competitive Inhibition65%
mentions🧪Stress Granule Phase Separation Modulators65%
mentions🧪Serine/Arginine-Rich Protein Kinase Modulation65%
mentions🧪Vocal Cord Neuroplasticity Stimulation65%
mentions🧪Nucleolar Stress Response Normalization65%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr63%
mentions🧫ALS Regional Onset and Spread: Network-Level Staging Model60%
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration60%
mentions🧫CRISPR Gene Correction Approaches for CBS/PSP60%
mentions🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M60%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS60%
mentions🧫TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an60%
see_also📖ACTB Gene60%
see_also📖Packard Center for ALS Research60%
see_also📖ABCA7 (Redirect)60%
see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
related🧪Mitochondrial-Lysosomal Contact Site Engineering58%
related🧪Arginine Methylation Enhancement Therapy58%
related🧪Cryptic Exon Silencing Restoration58%
related🧪Heat Shock Protein 70 Disaggregase Amplification58%
related🧪Low Complexity Domain Cross-Linking Inhibition58%
related🧪Glycine-Rich Domain Competitive Inhibition58%
related🧪Stress Granule Phase Separation Modulators58%
related🧪Serine/Arginine-Rich Protein Kinase Modulation58%
related🧪Vocal Cord Neuroplasticity Stimulation58%
related🧪Nucleolar Stress Response Normalization58%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model54%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration54%
related🧫CRISPR Gene Correction Approaches for CBS/PSP54%
related🧫Frontal and Temporal Lobe Selective Vulnerability in FTD — M54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
related🧫TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism an54%
mentions🧪Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics50%
mentions🧪Autophagosome Maturation Checkpoint Control50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪Axonal RNA Transport Reconstitution50%
mentions🧪Circadian-Gated Maresin Biosynthesis Amplification50%
mentions🧪Lysosomal Membrane Repair Enhancement50%
mentions🧪Senescence-Associated Myelin Lipid Remodeling50%
mentions🧪R-Loop Resolution Enhancement Therapy50%
mentions🧪Cross-Seeding Prevention Strategy50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
mentions🧪Phase-Separated Organelle Targeting50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar50%
mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT40%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study40%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Smartphone-Detected Motor Variability Correction40%
related🧪Circadian-Synchronized Proteostasis Enhancement40%
related🧪Mitochondrial RNA Granule Rescue Pathway40%
related🧪Multi-Modal Stress Response Harmonization40%
related🧪Retinal Vascular Microcirculation Rescue40%
related🧪Autophagosome Maturation Checkpoint Control40%
related🧪PARP1 Inhibition Therapy40%
related🧪Ocular Immune Privilege Extension40%
related🧪Axonal RNA Transport Reconstitution40%
related🧪Lysosomal Membrane Repair Enhancement40%
related🧪Lysosomal Calcium Channel Modulation Therapy40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪Digital Twin-Guided Metabolic Reprogramming40%
related🧪Lysosomal Positioning Dynamics Modulation40%
related🧪Lysosomal Enzyme Trafficking Correction40%
related🧪R-Loop Resolution Enhancement Therapy40%
related🧪Cross-Seeding Prevention Strategy40%
related🧪RNA Granule Nucleation Site Modulation40%
related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%
related🧪Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics40%
related🧪Autophagosome Maturation Checkpoint Control40%
related🧪PARP1 Inhibition Therapy40%
related🧪Axonal RNA Transport Reconstitution40%
related🧪Circadian-Gated Maresin Biosynthesis Amplification40%
related🧪Lysosomal Membrane Repair Enhancement40%
related🧪Senescence-Associated Myelin Lipid Remodeling40%
related🧪R-Loop Resolution Enhancement Therapy40%
related🧪Cross-Seeding Prevention Strategy40%
related🔬What are the mechanisms underlying rna binding protein dysre40%
related🔬RNA binding protein dysregulation across ALS FTD and AD40%
related🔬TDP-43 undergoes liquid-liquid phase separation that becomes40%
related🔬What are the mechanisms underlying digital biomarkers and ai40%
related🔬Can speech, gait, retinal imaging, sleep, and smartphone dat40%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
related🔬Multiple NDDs converge on autophagy-lysosome dysfunction. Ar40%
related🔬What are the mechanisms underlying tdp-43 phase separation t39%
mentions🔬What are the mechanisms underlying tdp-43 phase separation t35%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬What are the mechanisms underlying digital biomarkers and ai35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying neuroinflammation resolut35%
mentions🔬What are the mechanisms underlying rna binding protein dysre35%
mentions🔬What are the mechanisms underlying synaptic pruning by micro35%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di35%

💬 Discussion

SciDEX — scidex.ai — Dashboard | Mission Control | Status | How it Works | GitHub