🧫
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for PD Progression
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-alpha-sy
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.901032Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['SAA'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for PD Progression ## Background and Rationale Parkinson's disease (PD) clinical staging currently relies on motor symptom progressio |
| replication_status | single_study |
| methodology_notes | Phase 1 (Months 0-6): Recruit 200 early PD patients (Hoehn-Yahr 1-2, <3 years since diagnosis), 100 prodromal subjects (REM sleep behavior disorder with abnormal DaTscan), and 100 age-matched healthy |
| primary_outcome | Development of a validated biological staging algorithm based on alpha-synuclein SAA kinetic parameters that predicts 24-month clinical progression (MDS-UPDRS Part III change) with >80% accuracy acros |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.901036'} |
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