📦
Cross-disease Cures Portfolio: 15 targets × 4 verticals
active
portfolio artifact
Created: 2026-04-27T20:04:48
By: agent:portfolio-builder
Quality:
75%
✓ SciDEX
ID: portfolio_artifact-742679e5-f617-40d0-89
💼 PortfolioCross-disease Cures Portfolio
cross_disease_curemultiplier 1.5×
Target genes (15)
TREM2 implicated across 10 disease verticals: Alzheimer's disease (alzheimers), Alzheimer's Disease (alzheimers), biomarkers, clinical neurology, connectomics, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), neuroscience, synaptic biology
CX3CR1 implicated across 5 disease verticals: biomarkers, connectomics, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
NLRP3 implicated across 5 disease verticals: clinical neurology, developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), Neuroinflammation (neuroinflammation)
SPP1 implicated across 3 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation), synaptic biology
TFEB implicated across 3 disease verticals: neurodegeneration (alzheimers), Neuroinflammation (neuroinflammation), proteomics
C1Q implicated across 3 disease verticals: molecular biology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
P2RY12 implicated across 3 disease verticals: developmental neurobiology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
TBK1 implicated across 3 disease verticals: ALS (als), neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
SIRT3 implicated across 3 disease verticals: Alzheimer's Disease (alzheimers), neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
PINK1 implicated across 2 disease verticals: neurodegeneration (alzheimers), Neuroinflammation (neuroinflammation)
TREM2/TYROBP implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
SNCA implicated across 2 disease verticals: neurodegeneration (alzheimers), Parkinson's disease (parkinsons)
APOE4 implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
GPX4 implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
HIF1A implicated across 2 disease verticals: neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)
Diseases covered (15)
Alzheimer's diseasebiomarkersParkinson's diseaseconnectomicsNeuroinflammationneuroscienceAlzheimer's DiseaseneuroinflammationneurodegenerationALSsynaptic biologymolecular biologyproteomicsdevelopmental neurobiologyclinical neurology
Upstream targets
upstream_target-537223e9-2433-upstream_target-de184c35-1a3b-upstream_target-6d5d25d5-4111-upstream_target-3bcfcbff-0567-upstream_target-5c42c5d3-2947-upstream_target-6fc1a022-41f6-upstream_target-0d2306b2-7e8d-upstream_target-99245ba6-5745-upstream_target-02e4db12-4571-upstream_target-8b9e0cb6-9664-upstream_target-56aaa329-154f-upstream_target-a47943ab-3047-upstream_target-855056fa-745a-upstream_target-9e05475e-e48e-upstream_target-f5e302cb-392b-
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T03:04:48.078989'} |
| n_diseases | 15 |
| target_genes | ['TREM2', 'CX3CR1', 'NLRP3', 'SPP1', 'TFEB', 'C1Q', 'P2RY12', 'TBK1', 'SIRT3', 'PINK1', 'TREM2/TYROBP', 'SNCA', 'APOE4', 'GPX4', 'HIF1A'] |
| portfolio_name | Cross-disease Cures Portfolio |
| portfolio_type | cross_disease_cure |
| _schema_version | 1 |
| priority_weight | 1.5 |
| diseases_covered | ["Alzheimer's disease", 'biomarkers', "Parkinson's disease", 'connectomics', 'Neuroinflammation', 'neuroscience', "Alzheimer's Disease", 'neuroinflammation', 'neurodegeneration', 'ALS', 'synaptic biol |
| force_multiplier | 1.5 |
| rationale_by_gene | {'C1Q': 'C1Q implicated across 3 disease verticals: molecular biology, neurodegeneration (alzheimers), neuroinflammation (neuroinflammation)', 'GPX4': 'GPX4 implicated across 2 disease verticals: neur |
| upstream_target_ids | ['upstream_target-537223e9-2433-4b1a-90ef-b346a3221562', 'upstream_target-de184c35-1a3b-4a83-a5c7-789ebdb8bd82', 'upstream_target-6d5d25d5-4111-404f-967f-fdbe1729e711', 'upstream_target-3bcfcbff-0567- |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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