BECN1 Gene

BECN1 Gene

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">BECN1 Gene</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>BECLIN1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>BECN1</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=BECLIN1" target="_blank">Search NCBI</a></td>
</tr>
</table>

Pathway Diagram

BECN1 Gene

Introduction

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">BECN1 Gene</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>BECLIN1</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>BECN1</td>
</tr>
<tr>
<td class="label">Type</td>
<td>Gene</td>
</tr>
<tr>
<td class="label">NCBI</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/?term=BECLIN1" target="_blank">Search NCBI</a></td>
</tr>
</table>

Pathway Diagram

Becn1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

:: infobox .infobox-gene [@hegdekar2023] Symbol: BECN1 [@yao2021] Full Name: Beclin 1 [@rusmini2019] Chromosomal Location: 17q21.31 [@chen2021] NCBI Gene ID: [9277](https://www.ncbi.nlm.nih.gov/gene/9277) [@yi2024] OMIM: [604378](https://www.omim.org/entry/604378) [@luo2020] Ensembl ID: [ENSG00000126581](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126581) [@beccari2023] UniProt: [Q14457](https://www.uniprot.org/uniprot/Q14457) Proteins: [Beclin-1](/proteins/beclin-1) Associated Diseases: [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Breast Cancer](/diseases/breast-cancer), [Neurodegeneration](/diseases/neurodegeneration)
::

Overview

BECN1 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of BECN1 is associated with neurodegenerative diseases including [Alzheimer's disease](/diseases/alzheimers-disease), [Parkinson's disease](/diseases/parkinsons-disease), and related disorders.

Function

BECN1 encodes Beclin-1, a key regulator of [autophagy](/entities/autophagy) and [apoptosis](/entities/apoptosis). Beclin-1 is part of the PI3K complex that initiates autophagosome formation. It plays a dual role in cell survival (via autophagy) and cell death (via apoptosis). In neurodegenerative diseases, impaired autophagy leads to accumulation of protein aggregates, and Beclin-1 expression is often reduced.

Expression

Beclin-1 is widely expressed in:

• Brain ([neurons](/entities/neurons) and glia)
• Heart, liver, kidney
• Moderate expression in [hippocampus](/brain-regions/hippocampus), [cortex](/brain-regions/cortex), cerebellum
• Higher expression during development

Key Publications

• [Autophagy Protein genes](/entities/autophagy-protein)
• [Neurodegeneration pathways](/diseases/neurodegeneration)
• [Gene index](/genes)

Background

The study of Becn1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

Pathway Diagram

The following diagram shows the key molecular relationships involving BECN1 Gene discovered through SciDEX knowledge graph analysis: