BECLIN1

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

BECLIN1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with Aging, Als, Alzheimer. Connected to 407 entities in the SciDEX knowledge graph.

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flowchart TD
    BECLIN1["BECLIN1<br/>Autophagy Regulator"]
    
    BCL2["BCL2<br/>Anti-apoptotic Protein"]
    PI3K["PI3K<br/>Kinase Pathway"]
    MTOR["mTOR<br/>Growth Regulator"]
    AKT["AKT<br/>Survival Kinase"]
    
    AUTOPHAGY["Autophagy<br/>Cellular Cleanup"]
    APOPTOSIS["Apoptosis<br/>Cell Death"]
    OXIDATIVE["Oxidative Stress<br/>Response"]
    BBB["Blood-Brain Barrier<br/>Integrity"]
    
    P62["P62/SQSTM1<br/>Autophagy Receptor"]
    HO1["HO-1<br/>Antioxidant Enzyme"]
    SIGMAR1["SIGMAR1<br/>ER Stress Sensor"]
    
    ALS["ALS<br/>Motor Neuron Disease"]
    MS["Multiple Sclerosis<br/>Demyelination"]
    INFLAMMATION["Neuroinflammation"]
    ANXIETY["Anxiety Disorders"]
    
    BECLIN1 --|"forms complex"|--> PI3K
    PI3K --|"activates"|--> AUTOPHAGY
    BECLIN1 --|"inhibited by"|--> BCL2
    BECLIN1 --|"regulated by"|--> MTOR
    MTOR --|"inhibits"|--> AUTOPHAGY
    AKT --|"activates"|--> MTOR
    
    AUTOPHAGY --|"clears"|--> P62
    AUTOPHAGY --|"protects"|--> BBB
    BECLIN1 --|"upregulates"|--> HO1
    HO1 --|"reduces"|--> OXIDATIVE
    
    BECLIN1 --|"interacts"|--> SIGMAR1
    SIGMAR1 --|"modulates"|--> OXIDATIVE
    
    BECLIN1 --|"dysregulated in"|--> ALS
    BECLIN1 --|"contributes to"|--> MS
    BECLIN1 --|"reduces"|--> INFLAMMATION
    BECLIN1 --|"associated with"|--> ANXIETY
    
    BCL2 --|"promotes"|--> APOPTOSIS
    
    style BECLIN1 fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style HO1 fill:#1b5e20
    style BBB fill:#1b5e20
    style BCL2 fill:#4a1a6b
    style PI3K fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style AKT fill:#4a1a6b
    style SIGMAR1 fill:#4a1a6b
    style OXIDATIVE fill:#ef5350
    style APOPTOSIS fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style ANXIETY fill:#5d4400