Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about E2F2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
E2F2 is a gene implicated in neurodegeneration research. Key relationships include: treats, activates, regulates. Associated with ALS, Als, Cancer. Connected to 22 entities in the SciDEX knowledge graph.
| Gene Symbol | E2F2 |
| Full Name | E2F Transcription Factor 2 |
| Chromosome | 1p36.22 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Amino Acids | 404 aa |
| Pathways | Cell Cycle |
| UniProt ID | Q14209 |
| NCBI Gene ID | 1870 |
| GeneCards | E2F2 |
| Human Protein Atlas | E2F2 |
| Associated Diseases | neurodegeneration |
| Interactions | E2F3, E2F7, E2F8, E2F4, RORA, UBIQUITIN |
| KG Connections | 55 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
E2F2["<b>E2F2</b>"]
Ms{"Ms"}
E2F2 -->|"activates"| Ms
Als{"Als"}
E2F2 -->|"regulates"| Als
ALS{"ALS"}
E2F2 -->|"regulates"| ALS
E2F3["E2F3"]
E2F2 -->|"activates"| E2F3
E2F7["E2F7"]
E2F2 -->|"activates"| E2F7
E2F8["E2F8"]
E2F2 -->|"activates"| E2F8
Cell_Cycle(["Cell Cycle"])
E2F2 -->|"regulates"| Cell_Cycle
T_Cell["T Cell"]
E2F2 -->|"expressed in"| T_Cell
neurodegeneration["neurodegeneration"]
E2F2 -->|"implicated in"| neurodegeneration
E2F7 -->|"activates"| E2F2
E2F8 -->|"activates"| E2F2
E2F1["E2F1"]
E2F1 -->|"activates"| E2F2
DNA["DNA"]
DNA -->|"regulates"| E2F2
AND["AND"]
AND -->|"activates"| E2F2
style E2F2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| endocycle | regulates | process | 0.90 |
| G2/M transcriptional program | drives | pathway | 0.80 |
| Ms | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Ovarian Cancer | treats | disease | 0.65 |
| Cancer | treats | disease | 0.65 |
| Als | treats | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| E2F3 | activates | gene | 0.60 |
| E2F7 | activates | gene | 0.60 |
| E2F8 | activates | gene | 0.60 |
| E2F4 | interacts_with | gene | 0.60 |
| RORA | interacts_with | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| E2F1 | activates | gene | 0.60 |
| ELAVL1 | expressed_in | gene | 0.60 |
| GRID2 | expressed_in | gene | 0.60 |
| MAPK7 | expressed_in | gene | 0.60 |
| RIPK2 | expressed_in | gene | 0.60 |
| UHRF1 | expressed_in | gene | 0.60 |
| GRID2 | biomarker_for | gene | 0.60 |
| RIPK2 | biomarker_for | gene | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| CANCER | treats | gene | 0.60 |
| Metastasis | treats | pathway | 0.60 |
| Chemoresistance | treats | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Hepatocyte | regulates | cell_type | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| G6PD | expressed_in | gene | 0.60 |
| MAP | expressed_in | gene | 0.60 |
| MAPK | expressed_in | gene | 0.60 |
| MRPS31 | expressed_in | gene | 0.60 |
| necroptosis | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| E2F7 | activates | gene | 0.60 |
| E2F8 | activates | gene | 0.60 |
| E2F1 | activates | gene | 0.60 |
| TP53 | treats | gene | 0.60 |
| CD8 | activates | gene | 0.60 |
| E2F3 | activates | gene | 0.60 |
| ABCA7 | expressed_in | gene | 0.60 |
| ARF1 | expressed_in | gene | 0.60 |
| ATG7 | expressed_in | gene | 0.60 |
| ABCA7 | biomarker_for | gene | 0.60 |
| APC | activates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| MHC-I | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||