gene

E2F2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about E2F2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections
0Hypotheses
0Analyses
41Outgoing
14Incoming

Summary

E2F2 is a gene implicated in neurodegeneration research. Key relationships include: treats, activates, regulates. Associated with ALS, Als, Cancer. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolE2F2
Full NameE2F Transcription Factor 2
Chromosome1p36.22
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids404 aa
PathwaysCell Cycle
UniProt IDQ14209
NCBI Gene ID1870
GeneCardsE2F2
Human Protein AtlasE2F2
Associated Diseasesneurodegeneration
InteractionsE2F3, E2F7, E2F8, E2F4, RORA, UBIQUITIN
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: E2F2 — AlphaFold Q14209 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

E2F Transcription Factor 2

gene · 611 words

E2F4 Gene

gene · 2417 words

E2F8 Gene

gene · 1816 words

E2F5 Gene

gene · 1671 words

E2F Transcription Factor 2

protein · 1558 words

BRD2 (Bromodomain-Containing Protein 2)

gene · 1039 words

Pathway Diagram

graph TD
    E2F2["<b>E2F2</b>"]
    Ms{"Ms"}
    E2F2 -->|"activates"| Ms
    Als{"Als"}
    E2F2 -->|"regulates"| Als
    ALS{"ALS"}
    E2F2 -->|"regulates"| ALS
    E2F3["E2F3"]
    E2F2 -->|"activates"| E2F3
    E2F7["E2F7"]
    E2F2 -->|"activates"| E2F7
    E2F8["E2F8"]
    E2F2 -->|"activates"| E2F8
    Cell_Cycle(["Cell Cycle"])
    E2F2 -->|"regulates"| Cell_Cycle
    T_Cell["T Cell"]
    E2F2 -->|"expressed in"| T_Cell
    neurodegeneration["neurodegeneration"]
    E2F2 -->|"implicated in"| neurodegeneration
    E2F7 -->|"activates"| E2F2
    E2F8 -->|"activates"| E2F2
    E2F1["E2F1"]
    E2F1 -->|"activates"| E2F2
    DNA["DNA"]
    DNA -->|"regulates"| E2F2
    AND["AND"]
    AND -->|"activates"| E2F2
    style E2F2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

TargetRelationTypeStr
endocycleregulatesprocess0.90
G2/M transcriptional programdrivespathway0.80
Msactivatesdisease0.65
Alsregulatesdisease0.65
ALSregulatesdisease0.65

Incoming (14)

SourceRelationTypeStr
E2F7activatesgene0.60
E2F8activatesgene0.60
E2F1activatesgene0.60
TP53treatsgene0.60
CD8activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found