gene 611 words KG: E2F2 2026-03-22
kind:genesection:genesstate:published
Contents

E2F Transcription Factor 2

🧬 Gene Info
Gene SymbolE2F2
Full NameE2F Transcription Factor 2
Chromosome1p36.22
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids404 aa
PathwaysCell Cycle
UniProt IDQ14209
NCBI Gene ID1870
GeneCardsE2F2
Human Protein AtlasE2F2
Associated Diseasesneurodegeneration
InteractionsE2F3, E2F7, E2F8, E2F4, RORA, UBIQUITIN
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (25)

Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60

Related Analyses (23)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

E2F coordination of G2/M transcriptional program
exploratory · proposed · Score: 0.75
E2F regulation of endocycles in hepatocytes
validation · proposed · Score: 0.85
E2F regulation of endocycles in trophoblast giant cells
validation · proposed · Score: 0.85
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: regulates
NBR1 Gene
gene · KG edge: activates
E2F8 Gene
gene · KG edge: activates
E2F7 Gene
gene · KG edge: activates
E2F4 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

E2F2 activates E2F3
E2F2 activates E2F7
E2F2 activates E2F8
E2F2 interacts_with E2F4
E2F2 interacts_with RORA
E2F2 activates UBIQUITIN
E2F2 activates NBR1
E2F2 activates E2F1
E2F2 regulates endocycle
E2F2 drives G2/M transcriptional program