ESCO1 (Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1) is a lysine acetyltransferase that modifies the SMC3 subunit of the cohesin complex, a critical step in establishing sister chromatid cohesion during DNA replication. Together with its paralog ESCO2, ESCO1 regulates chromosome segregation, DNA repair, and gene expression programs essential for genomic stability and cellular function[@rolef2008].
Function
SMC3 Acetylation
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ESCO1 - Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1
ESCO1 (Establishment of Sister Chromatid Cohesion N-Acetyltransferase 1) is a lysine acetyltransferase that modifies the SMC3 subunit of the cohesin complex, a critical step in establishing sister chromatid cohesion during DNA replication. Together with its paralog ESCO2, ESCO1 regulates chromosome segregation, DNA repair, and gene expression programs essential for genomic stability and cellular function[@rolef2008].
Function
SMC3 Acetylation
ESCO1 catalyzes the acetylation of two evolutionarily conserved lysine residues on SMC3 (K105 and K106 in humans), which:
[Human Protein Atlas: ESCO1](https://www.proteinatlas.org/ENSG00000131931-ESCO1)
References
[Rolef Ben-Shahar T, et al, Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion (2008)](https://doi.org/10.1126/science.1157774)
[Unal E, et al, A molecular determinant for the establishment of sister chromatid cohesion (2008)](https://doi.org/10.1126/science.1157880)
[Alomer RM, et al, Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression (2017)](https://doi.org/10.1073/pnas.1702622114)
[Watrin E, Peters JM, The cohesin complex is required for the DNA damage-induced G2/M checkpoint (2006)](https://doi.org/10.1016/j.molcel.2006.07.018)
[Merkenschlager M, Odom DT, CTCF and cohesin: linking gene regulatory elements with disease genes (2013)](https://doi.org/10.1016/j.cell.2013.02.029)
[Rieger C, et al, Somatic mutations of ESCO1 and ESCO2 genes in bladder cancer (2019)](https://doi.org/10.1038/s41598-019-50349-9)
[Kon A, et al, Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms (2013)](https://doi.org/10.1038/ng.2731)
[Zhang J, et al, ESCO1 and ESCO2 play overlapping and distinct roles in sister chromatid cohesion (2019)](https://doi.org/10.1016/j.celrep.2019.06.017)
[Mondal G, et al, Functional consequences of mutations in the cohesin acetyltransferase ESCO1 in cancer (2020)](https://doi.org/10.1016/j.celrep.2020.107939)