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GPNMB Gene

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-gpnmb

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slug	genes-gpnmb
entity_type	gene
kg_node_id	GPNMB

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Linked Artifacts (62)

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see_also📖ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member 160%

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mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Complement C1q Mimetic Decoy Therapy50%

mentions🧪Complement C1q Subtype Switching50%

mentions🧪Complement C1QA Spatial Gradient in Cortical Layers50%

mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor50%

mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%

mentions🧪Netrin-1 Gradient Restoration50%

mentions🧪Microglial Purinergic Reprogramming50%

mentions🧪Purinergic P2Y12 Inverse Agonist Therapy50%

mentions🧪Autophagosome Maturation Checkpoint Control50%

mentions🧪Low Complexity Domain Cross-Linking Inhibition50%

mentions🧪VCP-Mediated Autophagy Enhancement50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying neuroinflammation resolut50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

related🧪APOE Isoform Conversion Therapy50%

related🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%

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related🔬Investigate prion-like spreading of tau pathology through co50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer40%

related🧪CYP46A1 Overexpression Gene Therapy40%

related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th40%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides40%

mentions🔬What are the mechanisms underlying blood-brain barrier trans35%

mentions🔬What are the mechanisms underlying apoe4 structural biology 35%

mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas35%