GPNMB

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPNMB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GPNMB is a protein involved in neurodegeneration research. Key relationships include: biomarker for, associated with, activates. Associated with AD, ALI, ALS. Connected to 193 entities in the SciDEX knowledge graph.

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flowchart TD
    GPNMB["GPNMB<br/>(Glycoprotein NMB)"]
    
    %% Associated genes/proteins
    APOE["APOE<br/>(Apolipoprotein E)"]
    HMGB1["HMGB1<br/>(High Mobility Group<br/>Box 1 Protein)"]
    NPTX2["NPTX2<br/>(Neuronal Pentraxin 2)"]
    
    %% Pathways
    Complement["Complement<br/>Pathway"]
    Epigenetic["Epigenetic<br/>Regulation"]
    Apoptosis["Apoptosis<br/>Pathway"]
    
    %% Diseases - Protective
    PD_protect["Parkinson's Disease<br/>(Protection)"]
    ALS_protect["ALS<br/>(Protection)"]
    
    %% Diseases - Associated/Biomarker
    AD["Alzheimer's<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    
    %% Pathological processes
    Inflammation["Neuroinflammation"]
    Senescence["Cellular<br/>Senescence"]
    Fibrosis["Tissue<br/>Fibrosis"]
    
    %% Beneficial outcomes
    Longevity["Longevity<br/>Promotion"]
    
    %% Connections
    GPNMB -->|"protects against"| PD_protect
    GPNMB -->|"protects against"| ALS_protect
    GPNMB -->|"biomarker for"| AD
    GPNMB -->|"biomarker for"| MS
    GPNMB -->|"activates"| Complement
    GPNMB -->|"activates"| Epigenetic
    GPNMB -->|"activates"| HMGB1
    GPNMB -->|"associated with"| APOE
    GPNMB -->|"associated with"| NPTX2
    GPNMB -->|"biomarker for"| Inflammation
    GPNMB -->|"biomarker for"| Senescence
    GPNMB -->|"biomarker for"| Fibrosis
    GPNMB -->|"biomarker for"| Longevity
    
    Complement -->|"regulates"| Apoptosis
    HMGB1 -->|"promotes"| Inflammation
    Inflammation -->|"contributes to"| AD
    Inflammation -->|"contributes to"| MS
    
    %% Styling
    style GPNMB fill:#006494
    style PD_protect fill:#1b5e20
    style ALS_protect fill:#1b5e20
    style Longevity fill:#1b5e20
    style AD fill:#ef5350
    style MS fill:#ef5350
    style Inflammation fill:#ef5350
    style Senescence fill:#ef5350
    style Fibrosis fill:#ef5350
    style APOE fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style NPTX2 fill:#4a1a6b
    style Complement fill:#5d4400
    style Epigenetic fill:#5d4400
    style Apoptosis fill:#5d4400