VCP-Mediated Autophagy Enhancement

**Molecular Mechanism and Rationale** The valosin-containing protein (VCP), also known as p97, represents a critical hexameric AAA+ ATPase that orchestrates multiple cellular quality control pathways, including autophagy, endoplasmic reticulum-associated degradation (ERAD), and proteasomal degradation. In the context of tauopathies, VCP functions as a key regulatory hub for tau aggregate clearance through its essential role in autophagosome maturation and lysosomal fusion. The molecular mechani...