Complement C1q Mimetic Decoy Therapy

**Molecular Mechanism and Rationale** The complement component 1q (C1q) represents a critical molecular bridge between innate immunity and synaptic plasticity in the central nervous system. C1q is a hexameric glycoprotein composed of three distinct polypeptide chains (C1qA, C1qB, and C1qC) that forms the recognition component of the classical complement pathway. Under physiological conditions, C1q is constitutively expressed by microglia and plays essential roles in developmental synaptic pruni...