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PRKN — Parkin RBR E3 Ubiquitin Protein Ligase

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-prkn

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slug	genes-prkn
entity_type	gene
kg_node_id	PRKN

Linked Artifacts (106)

mentions🧫Computational Modeling of Alpha-Synuclein Propagation in PD70%

mentions🧫Gap Junction Dysfunction Validation in Parkinson's Dise70%

mentions🧫Experiment: Multi-Ethnic PD GWAS70%

related🧫Computational Modeling of Alpha-Synuclein Propagation in PD63%

related🧫Gap Junction Dysfunction Validation in Parkinson's Dise63%

related🧫Experiment: Multi-Ethnic PD GWAS63%

see_also📖AMPK (AMP-Activated Protein Kinase)60%

see_also📖AIF1 Gene60%

see_also📖TOMM7060%

see_also📖Alzheimer Indonesia60%

see_also📖Packard Center for ALS Research60%

see_also📖TOMM70 Protein60%

see_also📖ATP1A3 Gene - Sodium-Potassium ATPase Alpha 360%

see_also📖DNAJC13 — DnaJ Heat Shock Protein Family Member C1360%

see_also📖KCNN3 — Potassium Calcium-Activated Channel Subfamily N Memb60%

see_also📖PINK1 — PTEN Induced Kinase 1 (PARK6)60%

see_also📖SYNJ1 — Synaptojanin 160%

see_also📖VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖Accelerating Medicines Partnership for Parkinson's Dise60%

see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%

see_also📖Dopamine Receptor Neurons60%

see_also📖Accelerating Medicines Partnership for Alzheimer's Dise60%

see_also📖ABCD3 Gene60%

see_also📖ACTB Gene60%

see_also📖ambra160%

see_also📖tmx260%

see_also📖Ubiquitin-Proteasome System Therapeutic Companies for Parkin60%

see_also📖Mitochondria60%

see_also📖PPP2R2B Gene60%

see_also📖Mitochondrial Quality Control60%

mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%

mentions🧪Extracellular Vesicle Biogenesis Modulation50%

mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%

mentions🧪Near-infrared light therapy stimulates COX4-dependent mitoch50%

mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%

mentions🧫Computational Modeling of Alpha-Synuclein Propagation in PD50%

mentions🧫Ferroptosis Validation in Parkinson's Disease50%

mentions🧫Gap Junction Dysfunction Validation in Parkinson's Dise50%

mentions🧫Experiment: Multi-Ethnic PD GWAS50%

mentions🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin50%

mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%

mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%

mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Stress Granule Phase Separation Modulators50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪RNA Granule Nucleation Site Modulation50%

mentions🧪Mitochondrial Transfer Pathway Enhancement50%

mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying epigenetic clocks and bio50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying epigenetic clocks and bio50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬RNA binding protein dysregulation across ALS FTD and AD50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬Epigenetic reprogramming in aging neurons50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

related🧪Mitochondrial-Lysosomal Contact Site Engineering40%

related🧪Autophagosome Maturation Checkpoint Control40%

related🧪Lysosomal Membrane Repair Enhancement40%

related🧪Lysosomal Calcium Channel Modulation Therapy40%

related🧪Transcriptional Autophagy-Lysosome Coupling40%

related🧪Lysosomal Positioning Dynamics Modulation40%

related🧪Lysosomal Enzyme Trafficking Correction40%

related🧪Mitochondrial-Lysosomal Contact Site Engineering40%

related🧪Extracellular Vesicle Biogenesis Modulation40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%

related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%

related🧪FOXO3-Longevity Pathway Epigenetic Reprogramming40%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa40%

related🔬Multiple NDDs converge on autophagy-lysosome dysfunction. Ar40%

mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%

mentions🔬What are the mechanisms underlying what are the mechanisms b35%

mentions🔬What are the mechanisms underlying mitochondrial transfer be35%

mentions🔬What are the mechanisms underlying epigenetic clocks and bio35%

mentions🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc35%

mentions🔬Investigate prion-like spreading of tau pathology through co35%

related🔬What are the mechanisms underlying tdp-43 phase separation t30%