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OPTN — Optineurin

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-optn

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slug	genes-optn
entity_type	gene
kg_node_id	OPTN

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Linked Artifacts (97)

see_also📖nucleus-accumbens60%

see_also📖AIF1 Gene60%

see_also📖rab10 Gene60%

see_also📖RAD18 Gene60%

see_also📖deferiprone-neurodegeneration60%

see_also📖ABCA7 (Redirect)60%

see_also📖UBQLN2 Protein (Ubiquilin-2)60%

see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%

see_also📖DPM2 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 2)60%

see_also📖GLB1 Gene60%

see_also📖SAMHD1 — SAM and HD Domain Containing Metal Dependent Hydrol60%

see_also📖SPART — Spartin60%

see_also📖ubqln260%

see_also📖VPS4A — Vacuolar Protein Sorting 4 Homolog A60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖UBQLN2 Protein60%

see_also📖NDUFS4 Gene60%

see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%

see_also📖Retinal Ganglion Cells60%

see_also📖Retinal Ganglion Cells (RGCs)60%

see_also📖Retinal Ganglion Cells in Alzheimer's Disease60%

see_also📖Retinal Ganglion Cells in Leber Hereditary Optic Neuropathy60%

see_also📖Retinal Ganglion Cells in Neurodegeneration60%

see_also📖Retinal Ganglion Cells in Visual Transmission60%

see_also📖Retinal Ganglion Cells in Glaucoma60%

see_also📖Retinal Ganglion Cells in Leber Hereditary Optic Neuropathy60%

see_also📖Mitochondria60%

see_also📖Accelerating Medicines Partnership for Alzheimer's Dise60%

see_also📖Dementia Australia60%

see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%

see_also📖Ubiquitin-Proteasome System Therapeutic Companies for Parkin60%

see_also📖p62/SQSTM1 (Sequestosome-1)60%

see_also📖ABCD3 Gene60%

see_also📖ACTB Gene60%

see_also📖AKT1 Gene60%

see_also📖FLNA Gene60%

see_also📖GABRP — GABA-A Receptor Pi Subunit60%

see_also📖MAP3K1 — Mitogen-Activated Protein Kinase Kinase Kinase 160%

see_also📖MYO5A — Myosin Va60%

see_also📖pex1460%

see_also📖TIMM23 — Translocase of Inner Mitochondrial Membrane 2360%

see_also📖Axonal Degeneration60%

see_also📖PPP2R2B Gene60%

see_also📖RAB32 Gene60%

see_also📖CCR7 Gene (C-C Chemokine Receptor Type 7)60%

related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro55%

mentions🧪Axonal RNA Transport Reconstitution50%

mentions🧪Transcriptional Autophagy-Lysosome Coupling50%

mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Lysosomal Membrane Repair Enhancement50%

mentions🧪Near-infrared light therapy stimulates COX4-dependent mitoch50%

mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%

mentions🧪Stress Granule Phase Separation Modulators50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪RNA Granule Nucleation Site Modulation50%

mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%

mentions🧪Mitochondrial Transfer Pathway Enhancement50%

mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%

mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%

mentions🧪Autophagosome Maturation Checkpoint Control50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪VCP-Mediated Autophagy Enhancement50%

mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬How does metabolic reprogramming (glucose metabolism shifts,50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying epigenetic clocks and bio50%

mentions🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri40%

mentions🧫Brainstem Circuit Modulation for PSP40%

mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT40%

mentions🧫CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi40%

mentions🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Axonal RNA Transport Reconstitution40%

related🧪Transcriptional Autophagy-Lysosome Coupling40%

mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%

mentions🔬What are the mechanisms underlying rna binding protein dysre35%

mentions🔬How does metabolic reprogramming (glucose metabolism shifts,35%