Hippocampal CA3 Pyramidal Neurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Hippocampal CA3 Pyramidal Neurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3455</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Glutamatergic > Hippocampal > CA3</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>SLC17A7, PROX1, CALB1, WFS1, CPNE7</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Hippocampus CA3</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Epilepsy](/diseases/epilepsy), Temporal lobe epilepsy</td>
</tr>
</table>
Hippocampal CA3 Pyramidal Neurons
Introduction
Hippocampal Ca3 Pyramidal Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
...Hippocampal CA3 Pyramidal Neurons
<table class="infobox infobox-celltype">
<tr>
<th class="infobox-header" colspan="2">Hippocampal CA3 Pyramidal Neurons</th>
</tr>
<tr>
<td class="label">Allen Atlas ID</td>
<td><a href="https://portal.brain-map.org/atlases-and-data/rnaseq" target="_blank">CS202210140_3455</a></td>
</tr>
<tr>
<td class="label">Lineage</td>
<td>Neuron > Glutamatergic > Hippocampal > CA3</td>
</tr>
<tr>
<td class="label">Markers</td>
<td>SLC17A7, PROX1, CALB1, WFS1, CPNE7</td>
</tr>
<tr>
<td class="label">Brain Regions</td>
<td>Hippocampus CA3</td>
</tr>
<tr>
<td class="label">Disease Vulnerability</td>
<td>[Alzheimer's Disease](/diseases/alzheimers-disease), [Epilepsy](/diseases/epilepsy), Temporal lobe epilepsy</td>
</tr>
</table>
Hippocampal CA3 Pyramidal Neurons
Introduction
Hippocampal Ca3 Pyramidal Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Mermaid diagram (expand to render)
Hippocampal CA3 Pyramidal Neurons are a specialized cell type classified within the Neuron > Glutamatergic > Hippocampal > CA3 lineage. These cells are primarily found in Hippocampus CA3 and are characterized by expression of marker genes including SLC17A7, PROX1, CALB1, WFS1. They are selectively vulnerable in Alzheimer's Disease, Epilepsy, Temporal lobe epilepsy.
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Multi-Taxonomy Classification
Taxonomy Database Cross-References
| Taxonomy | ID | Name / Label |
|----------|----|---------------|
| Cell Ontology (CL) | [CL:0000598](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000598) | pyramidal neuron |
Morphology & Electrophysiology
- Morphology: pyramidal neuron (source: Cell Ontology)
- Morphology can be inferred from Cell Ontology classification
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000598)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000598)
- [OBO Foundry (CL:0000598)](http://purl.obolibrary.org/obo/CL_0000598)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [Human Cell Atlas](https://www.humancellatlas.org/)
- [PanglaoDB](https://panglaodb.se/)
Taxonomy & Classification
| Database | ID | Name | Confidence |
|----------|----|------|------------|
| Cell Ontology | [CL:0000598](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000598) | pyramidal neuron | Medium |
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000598)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000598)
- [OBO Foundry (CL:0000598)](http://purl.obolibrary.org/obo/CL_0000598)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [PanglaoDB](https://panglaodb.se/)
Morphology and Markers
Hippocampal CA3 Pyramidal Neurons are identified by the expression of the following key marker genes:
- SLC17A7
- PROX1
- CALB1
- WFS1
- CPNE7
These markers are used for immunohistochemical identification and single-cell RNA sequencing classification, as catalogued in the [Allen Cell Type Atlas](https://portal.brain-map.org/atlases-and-data/rnaseq).
Normal Function
Hippocampal CA3 Pyramidal Neurons play essential roles in neural circuits and brain function. They are found in the following brain regions:
Their normal functions include maintaining neural circuit integrity, signal processing, and contributing to the homeostasis of their local microenvironment.
Vulnerability in Disease
Hippocampal CA3 Pyramidal Neurons show selective vulnerability in the following neurodegenerative conditions:
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- Epilepsy
- Temporal lobe epilepsy
The selective vulnerability of these cells is an active area of research, with factors including metabolic demands, calcium handling, exposure to toxic protein aggregates, and cell-autonomous gene expression programs contributing to their susceptibility.
Transcriptomic Profile
Single-cell and single-nucleus RNA sequencing studies have revealed the transcriptomic signature of Hippocampal CA3 Pyramidal Neurons. Key differentially expressed genes from the Allen Cell Type Atlas and related datasets include the marker genes listed above. These transcriptomic profiles help identify subtypes and disease-associated gene expression changes.
Key Publications
[CA3 pyramidal neuron dysfunction in epilepsy and AD](https://doi.org/10.1038/s41583-021-00451-9). Nat Rev Neurosci, 2021.
External Links
- Allen Cell Type Atlas: [https://portal.brain-map.org/atlases-and-data/rnaseq](https://portal.brain-map.org/atlases-and-data/rnaseq)
- Allen Human Brain Atlas: [https://human.brain-map.org/](https://human.brain-map.org/)
- [Cell Types Index](/cell-types)- [Diseases Index](/diseases)eases Index
- [Mechanisms Index](/mechanisms) --
Background
The study of Hippocampal Ca3 Pyramidal Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.